GOLPH3 modulates mTOR signaling and rapamycin sensitivity in cancer

Genome-wide copy number analyses of human cancers identified a frequent 5p13 amplification in multiple solid tumor types, including lung (56%), ovarian (38%), breast (32%), prostate (37%) and melanoma (32%). Integrative analysis of the region identifies a Golgi protein, GOLPH3, as a candidate target...

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Detalles Bibliográficos
Autores principales: Scott, Kenneth L., Kabbarah, Omar, Liang, Mei-Chih, Ivanova, Elena, Anagnostou, Valsamo, Wu, Joyce, Dhakal, Sabin, Wu, Min, Chen, Shujuan, Feinberg, Tamar, Huang, Joseph, Saci, Abdel, Widlund, Hans R., Fisher, David E., Xiao, Yonghong, Rimm, David L., Protopopov, Alexei, Wong, Kwok-Kin, Chin, Lynda
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753613/
https://www.ncbi.nlm.nih.gov/pubmed/19553991
http://dx.doi.org/10.1038/nature08109

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