TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA

Toll-like receptor 9 (TLR9) promiscuously binds self and microbial DNA, but only microbial DNA elicits an inflammatory response. How TLR9 discriminates between self and foreign DNA is unclear, but inappropriate localization of TLR9 permits response to self DNA, suggesting that TLR9 localization and...

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Detalles Bibliográficos
Autores principales: Chockalingam, Annapoorani, Brooks, James C., Cameron, Jody L., Blum, Lisa K., Leifer, Cynthia A.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753824/
https://www.ncbi.nlm.nih.gov/pubmed/19079358
http://dx.doi.org/10.1038/icb.2008.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753824/
https://www.ncbi.nlm.nih.gov/pubmed/19079358
http://dx.doi.org/10.1038/icb.2008.101

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