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Lack of regulation of 11β-hydroxysteroid dehydrogenase type 1 during short-term manipulation of GH in patients with hypopituitarism

OBJECTIVE: Evidence from long-term clinical studies measuring urinary steroid ratios, and from in vitro studies, suggests that GH administered for longer than 2 months down-regulates 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), thereby reducing cortisol regeneration in liver and adipose tissu...

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Detalles Bibliográficos
Autores principales:	Sigurjonsdottir, Helga A, Andrew, Ruth, Stimson, Roland H, Johannsson, Gudmundur, Walker, Brian R
Formato:	Texto
Lenguaje:	English
Publicado:	BioScientifica 2009
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754375/ https://www.ncbi.nlm.nih.gov/pubmed/19549748 http://dx.doi.org/10.1530/EJE-09-0315

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