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The pK(a) Distribution of Drugs: Application to Drug Discovery
The acid-base dissociation constant (pK(a)) of a drug is a key physicochemical parameter influencing many biopharmaceutical characteristics. While this has been well established, the overall proportion of non-ionizable and ionizable compounds for drug-like substances is not well known. Even less wel...
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| Formato: | Texto |
| Lenguaje: | English |
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Libertas Academica
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754920/ https://www.ncbi.nlm.nih.gov/pubmed/19812734 |