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The pK(a) Distribution of Drugs: Application to Drug Discovery

The acid-base dissociation constant (pK(a)) of a drug is a key physicochemical parameter influencing many biopharmaceutical characteristics. While this has been well established, the overall proportion of non-ionizable and ionizable compounds for drug-like substances is not well known. Even less wel...

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Detalles Bibliográficos
Autor principal: Manallack, David T.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754920/
https://www.ncbi.nlm.nih.gov/pubmed/19812734

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