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Adult reversal of cognitive phenotypes in neurodevelopmental disorders

Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatric phenotypes of a range of common mental health problems wit...

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Detalles Bibliográficos
Autores principales: Silva, Alcino J., Ehninger, Dan
Formato: Texto
Lenguaje:English
Publicado: Springer US 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755132/
https://www.ncbi.nlm.nih.gov/pubmed/19812701
http://dx.doi.org/10.1007/s11689-009-9018-7
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author Silva, Alcino J.
Ehninger, Dan
author_facet Silva, Alcino J.
Ehninger, Dan
author_sort Silva, Alcino J.
collection PubMed
description Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatric phenotypes of a range of common mental health problems with a clear developmental component. As a consequence, most researchers have focused their efforts on understanding the molecular and cellular processes that alter development with the hope that early intervention could prevent the emergent pathology. Unexpectedly, several different animal model studies published recently, including animal models of autism, suggest that it may be possible to reverse neurodevelopmental disorders in adults: Addressing the underlying molecular and cellular deficits in adults could in several cases dramatically improve the neurocognitive phenotypes in these animal models. The findings reviewed here provide hope to millions of individuals afflicted with a wide range of neurodevelopmental disorders, including autism, since they suggest that it may be possible to treat or even cure them in adults.
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spelling pubmed-27551322009-10-06 Adult reversal of cognitive phenotypes in neurodevelopmental disorders Silva, Alcino J. Ehninger, Dan J Neurodev Disord Article Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatric phenotypes of a range of common mental health problems with a clear developmental component. As a consequence, most researchers have focused their efforts on understanding the molecular and cellular processes that alter development with the hope that early intervention could prevent the emergent pathology. Unexpectedly, several different animal model studies published recently, including animal models of autism, suggest that it may be possible to reverse neurodevelopmental disorders in adults: Addressing the underlying molecular and cellular deficits in adults could in several cases dramatically improve the neurocognitive phenotypes in these animal models. The findings reviewed here provide hope to millions of individuals afflicted with a wide range of neurodevelopmental disorders, including autism, since they suggest that it may be possible to treat or even cure them in adults. Springer US 2009-06-17 /pmc/articles/PMC2755132/ /pubmed/19812701 http://dx.doi.org/10.1007/s11689-009-9018-7 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Silva, Alcino J.
Ehninger, Dan
Adult reversal of cognitive phenotypes in neurodevelopmental disorders
title Adult reversal of cognitive phenotypes in neurodevelopmental disorders
title_full Adult reversal of cognitive phenotypes in neurodevelopmental disorders
title_fullStr Adult reversal of cognitive phenotypes in neurodevelopmental disorders
title_full_unstemmed Adult reversal of cognitive phenotypes in neurodevelopmental disorders
title_short Adult reversal of cognitive phenotypes in neurodevelopmental disorders
title_sort adult reversal of cognitive phenotypes in neurodevelopmental disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755132/
https://www.ncbi.nlm.nih.gov/pubmed/19812701
http://dx.doi.org/10.1007/s11689-009-9018-7
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