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Adult reversal of cognitive phenotypes in neurodevelopmental disorders
Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatric phenotypes of a range of common mental health problems wit...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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Springer US
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755132/ https://www.ncbi.nlm.nih.gov/pubmed/19812701 http://dx.doi.org/10.1007/s11689-009-9018-7 |
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author | Silva, Alcino J. Ehninger, Dan |
author_facet | Silva, Alcino J. Ehninger, Dan |
author_sort | Silva, Alcino J. |
collection | PubMed |
description | Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatric phenotypes of a range of common mental health problems with a clear developmental component. As a consequence, most researchers have focused their efforts on understanding the molecular and cellular processes that alter development with the hope that early intervention could prevent the emergent pathology. Unexpectedly, several different animal model studies published recently, including animal models of autism, suggest that it may be possible to reverse neurodevelopmental disorders in adults: Addressing the underlying molecular and cellular deficits in adults could in several cases dramatically improve the neurocognitive phenotypes in these animal models. The findings reviewed here provide hope to millions of individuals afflicted with a wide range of neurodevelopmental disorders, including autism, since they suggest that it may be possible to treat or even cure them in adults. |
format | Text |
id | pubmed-2755132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-27551322009-10-06 Adult reversal of cognitive phenotypes in neurodevelopmental disorders Silva, Alcino J. Ehninger, Dan J Neurodev Disord Article Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatric phenotypes of a range of common mental health problems with a clear developmental component. As a consequence, most researchers have focused their efforts on understanding the molecular and cellular processes that alter development with the hope that early intervention could prevent the emergent pathology. Unexpectedly, several different animal model studies published recently, including animal models of autism, suggest that it may be possible to reverse neurodevelopmental disorders in adults: Addressing the underlying molecular and cellular deficits in adults could in several cases dramatically improve the neurocognitive phenotypes in these animal models. The findings reviewed here provide hope to millions of individuals afflicted with a wide range of neurodevelopmental disorders, including autism, since they suggest that it may be possible to treat or even cure them in adults. Springer US 2009-06-17 /pmc/articles/PMC2755132/ /pubmed/19812701 http://dx.doi.org/10.1007/s11689-009-9018-7 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Silva, Alcino J. Ehninger, Dan Adult reversal of cognitive phenotypes in neurodevelopmental disorders |
title | Adult reversal of cognitive phenotypes in neurodevelopmental disorders |
title_full | Adult reversal of cognitive phenotypes in neurodevelopmental disorders |
title_fullStr | Adult reversal of cognitive phenotypes in neurodevelopmental disorders |
title_full_unstemmed | Adult reversal of cognitive phenotypes in neurodevelopmental disorders |
title_short | Adult reversal of cognitive phenotypes in neurodevelopmental disorders |
title_sort | adult reversal of cognitive phenotypes in neurodevelopmental disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755132/ https://www.ncbi.nlm.nih.gov/pubmed/19812701 http://dx.doi.org/10.1007/s11689-009-9018-7 |
work_keys_str_mv | AT silvaalcinoj adultreversalofcognitivephenotypesinneurodevelopmentaldisorders AT ehningerdan adultreversalofcognitivephenotypesinneurodevelopmentaldisorders |