Quetiapine: Relatively safe in overdose?

Compared to other antipsychotics quetiapine has been reported to be relatively safer in overdose. We report a case with paranoid schizophrenia who attempted suicide with 1400 mg of quetiapine and manifested drowsiness, supraventricular tachycardia (167/minute) and minimal ST depression in leads V1 t...

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Autores principales: Mattoo, Surendra K., Shah, Ruchita, Rajagopal, R., Biswas, Partha Sarathy, Singh, Shubh Mohan
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755169/
https://www.ncbi.nlm.nih.gov/pubmed/19823635
http://dx.doi.org/10.4103/0019-5545.49456
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author Mattoo, Surendra K.
Shah, Ruchita
Rajagopal, R.
Biswas, Partha Sarathy
Singh, Shubh Mohan
author_facet Mattoo, Surendra K.
Shah, Ruchita
Rajagopal, R.
Biswas, Partha Sarathy
Singh, Shubh Mohan
author_sort Mattoo, Surendra K.
collection PubMed
description Compared to other antipsychotics quetiapine has been reported to be relatively safer in overdose. We report a case with paranoid schizophrenia who attempted suicide with 1400 mg of quetiapine and manifested drowsiness, supraventricular tachycardia (167/minute) and minimal ST depression in leads V1 to V6 on ECG; all other physiological parameters were normal. Gastric lavage, lorazepam 2mg i/v to control agitation, and 14-hour observation in emergency ended in she being sent home. Subsequently she was successfully managed with ECTs, and quetiapine 600mg and risperidone 6mg daily. This report tends to support the literature suggesting quetiapine as a relatively-safer-in-overdose antipsychotic, and preferable in medication-overdose-suicidal-risk cases.
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spelling pubmed-27551692009-10-09 Quetiapine: Relatively safe in overdose? Mattoo, Surendra K. Shah, Ruchita Rajagopal, R. Biswas, Partha Sarathy Singh, Shubh Mohan Indian J Psychiatry Case Report Compared to other antipsychotics quetiapine has been reported to be relatively safer in overdose. We report a case with paranoid schizophrenia who attempted suicide with 1400 mg of quetiapine and manifested drowsiness, supraventricular tachycardia (167/minute) and minimal ST depression in leads V1 to V6 on ECG; all other physiological parameters were normal. Gastric lavage, lorazepam 2mg i/v to control agitation, and 14-hour observation in emergency ended in she being sent home. Subsequently she was successfully managed with ECTs, and quetiapine 600mg and risperidone 6mg daily. This report tends to support the literature suggesting quetiapine as a relatively-safer-in-overdose antipsychotic, and preferable in medication-overdose-suicidal-risk cases. Medknow Publications 2009 /pmc/articles/PMC2755169/ /pubmed/19823635 http://dx.doi.org/10.4103/0019-5545.49456 Text en © Indian Journal of Psychiatry http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mattoo, Surendra K.
Shah, Ruchita
Rajagopal, R.
Biswas, Partha Sarathy
Singh, Shubh Mohan
Quetiapine: Relatively safe in overdose?
title Quetiapine: Relatively safe in overdose?
title_full Quetiapine: Relatively safe in overdose?
title_fullStr Quetiapine: Relatively safe in overdose?
title_full_unstemmed Quetiapine: Relatively safe in overdose?
title_short Quetiapine: Relatively safe in overdose?
title_sort quetiapine: relatively safe in overdose?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755169/
https://www.ncbi.nlm.nih.gov/pubmed/19823635
http://dx.doi.org/10.4103/0019-5545.49456
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AT rajagopalr quetiapinerelativelysafeinoverdose
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AT singhshubhmohan quetiapinerelativelysafeinoverdose

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