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Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processing

We investigated whether a continuous transcript is necessary for co-transcriptional pre-mRNA processing. Cutting an intron with the fast-cleaving hepatitis δ ribozyme, but not the slower hammerhead, inhibited splicing. Exon tethering to RNA pol II therefore cannot rescue splicing of a transcript sev...

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Detalles Bibliográficos
Autores principales:	Fong, Nova, Ohman, Marie, Bentley, David L.
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755206/ https://www.ncbi.nlm.nih.gov/pubmed/19701200 http://dx.doi.org/10.1038/nsmb.1652

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