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Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease

INTRODUCTION: Molecular imaging aims towards the non-invasive characterization of disease-specific molecular alterations in the living organism in vivo. In that, molecular imaging opens a new dimension in our understanding of disease pathogenesis, as it allows the non-invasive determination of the d...

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Autores principales: Winkeler, A., Waerzeggers, Y., Klose, A., Monfared, P., Thomas, A. V., Schubert, M., Heneka, M. T., Jacobs, A. H.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755760/
https://www.ncbi.nlm.nih.gov/pubmed/18219484
http://dx.doi.org/10.1007/s00259-007-0710-0
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author Winkeler, A.
Waerzeggers, Y.
Klose, A.
Monfared, P.
Thomas, A. V.
Schubert, M.
Heneka, M. T.
Jacobs, A. H.
author_facet Winkeler, A.
Waerzeggers, Y.
Klose, A.
Monfared, P.
Thomas, A. V.
Schubert, M.
Heneka, M. T.
Jacobs, A. H.
author_sort Winkeler, A.
collection PubMed
description INTRODUCTION: Molecular imaging aims towards the non-invasive characterization of disease-specific molecular alterations in the living organism in vivo. In that, molecular imaging opens a new dimension in our understanding of disease pathogenesis, as it allows the non-invasive determination of the dynamics of changes on the molecular level. IMAGING OF AD CHARACTERISTIC CHANGES BY μPET: The imaging technology being employed includes magnetic resonance imaging (MRI) and nuclear imaging as well as optical-based imaging technologies. These imaging modalities are employed together or alone for disease phenotyping, development of imaging-guided therapeutic strategies and in basic and translational research. SUMMARY: In this study, we review recent investigations employing positron emission tomography and MRI for phenotyping mouse models of Alzheimers’ disease by imaging. We demonstrate that imaging has an important role in the characterization of mouse models of neurodegenerative diseases.
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spelling pubmed-27557602009-10-07 Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease Winkeler, A. Waerzeggers, Y. Klose, A. Monfared, P. Thomas, A. V. Schubert, M. Heneka, M. T. Jacobs, A. H. Eur J Nucl Med Mol Imaging Article INTRODUCTION: Molecular imaging aims towards the non-invasive characterization of disease-specific molecular alterations in the living organism in vivo. In that, molecular imaging opens a new dimension in our understanding of disease pathogenesis, as it allows the non-invasive determination of the dynamics of changes on the molecular level. IMAGING OF AD CHARACTERISTIC CHANGES BY μPET: The imaging technology being employed includes magnetic resonance imaging (MRI) and nuclear imaging as well as optical-based imaging technologies. These imaging modalities are employed together or alone for disease phenotyping, development of imaging-guided therapeutic strategies and in basic and translational research. SUMMARY: In this study, we review recent investigations employing positron emission tomography and MRI for phenotyping mouse models of Alzheimers’ disease by imaging. We demonstrate that imaging has an important role in the characterization of mouse models of neurodegenerative diseases. Springer-Verlag 2008-01-25 2008-03 /pmc/articles/PMC2755760/ /pubmed/18219484 http://dx.doi.org/10.1007/s00259-007-0710-0 Text en © Springer-Verlag 2007
spellingShingle Article
Winkeler, A.
Waerzeggers, Y.
Klose, A.
Monfared, P.
Thomas, A. V.
Schubert, M.
Heneka, M. T.
Jacobs, A. H.
Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease
title Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease
title_full Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease
title_fullStr Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease
title_full_unstemmed Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease
title_short Imaging noradrenergic influence on amyloid pathology in mouse models of Alzheimer’s disease
title_sort imaging noradrenergic influence on amyloid pathology in mouse models of alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755760/
https://www.ncbi.nlm.nih.gov/pubmed/18219484
http://dx.doi.org/10.1007/s00259-007-0710-0
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