Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation

The 21-kD protein Ras of the low-molecular-weight GTP-binding (LMWG) family plays an important role in transduction of extracellular signals. Ras functions as a ‘molecular switch’ in transduction of signals from the membrane receptors of many growth factors, cytokines, and other second messengers to...

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Detalles Bibliográficos
Autores principales: Raepple, D., von Lintig, F., Zemojtel, T., Duchniewicz, M., Jung, A., Lübbert, M., Boss, G. R., Scheele, J. S.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755762/
https://www.ncbi.nlm.nih.gov/pubmed/18784923
http://dx.doi.org/10.1007/s00277-008-0593-6

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