A novel, primate-specific, brain isoform of KCNH2 impacts cortical physiology, cognition, neuronal repolarization and risk for schizophrenia

Organized neuronal firing is critical for cortical processing and is disrupted in schizophrenia. Using 5’ RACE in human brain, we identified a primate-specific isoform (3.1) of the K(+)-channel KCNH2 that modulates neuronal firing. KCNH2-3.1 mRNA levels are comparable to KCNH2-1A in brain, but 1000-...

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Detalles Bibliográficos
Autores principales: Huffaker, Stephen J., Chen, Jingshan, Nicodemus, Kristin K., Sambataro, Fabio, Yang, Feng, Mattay, Venkata, Lipska, Barbara K., Hyde, Thomas M., Song, Jian, Rujescu, Daniel, Giegling, Ina, Mayilyan, Karine, Proust, Morgan J., Soghoyan, Armen, Caforio, Grazia, Callicott, Joseph H., Bertolino, Alessandro, Meyer-Lindenberg, Andreas, Chang, Jay, Ji, Yuanyuan, Egan, Michael F., Goldberg, Terry E., Kleinman, Joel E., Lu, Bai, Weinberger, Daniel R.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756110/
https://www.ncbi.nlm.nih.gov/pubmed/19412172
http://dx.doi.org/10.1038/nm.1962

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