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Intraclonal competition limits regulatory T cell fate determination in the thymus

Because the deletion of self-reactive T cells is incomplete, thymic development of natural Foxp3(+)CD4(+) regulatory T (T(reg)) cells is required for preventing autoimmunity. However, the role of T cell receptor (TCR) specificity in thymic T(reg) cell development remains controversial. To address th...

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Detalles Bibliográficos
Autores principales:	Bautista, Jhoanne L., Lio, Chan-Wang J., Lathrop, Stephanie K., Forbush, Katherine, Liang, Yuqiong, Luo, Jingqin, Rudensky, Alexander Y., Hsieh, Chyi-Song
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756247/ https://www.ncbi.nlm.nih.gov/pubmed/19430476 http://dx.doi.org/10.1038/ni.1739

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