Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation

Polyoma virus middle T antigen (PyVmT) is a powerful viral oncogene; however, the mechanisms of PyVmT activation are poorly understood. The IGF-I receptor (IGF-IR) and the insulin receptor (IR) are known to be implicated in the development of many cancers. Furthermore, PyVmT-overexpressing mouse mam...

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Detalles Bibliográficos
Autores principales: Novosyadlyy, R, Vijayakumar, A, Lann, D, Fierz, Y, Kurshan, N, LeRoith, D
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756316/
https://www.ncbi.nlm.nih.gov/pubmed/19617901
http://dx.doi.org/10.1038/onc.2009.209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756316/
https://www.ncbi.nlm.nih.gov/pubmed/19617901
http://dx.doi.org/10.1038/onc.2009.209

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