Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment

Toll-like receptors (TLRs) play a crucial role in the innate immune response and the subsequent induction of adaptive immune responses against microbial infection or tissue injury. Recent findings show that functional TLRs are expressed not only on immune cells but also on cancer cells. TLRs play an...

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Detalles Bibliográficos
Autores principales: Sato, Yusuke, Goto, Yasufumi, Narita, Norihiko, Hoon, Dave S.B.
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2009
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756339/
https://www.ncbi.nlm.nih.gov/pubmed/19685283
http://dx.doi.org/10.1007/s12307-009-0022-y
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author Sato, Yusuke
Goto, Yasufumi
Narita, Norihiko
Hoon, Dave S.B.
author_facet Sato, Yusuke
Goto, Yasufumi
Narita, Norihiko
Hoon, Dave S.B.
author_sort Sato, Yusuke
collection PubMed
description Toll-like receptors (TLRs) play a crucial role in the innate immune response and the subsequent induction of adaptive immune responses against microbial infection or tissue injury. Recent findings show that functional TLRs are expressed not only on immune cells but also on cancer cells. TLRs play an active role in carcinogenesis and tumor progression during chronic inflammation that involves the tumor microenvironment. Damage-associated molecular patterns (DAMPs) derived from injured normal epithelial cells and necrotic cancer cells appear to be present at significant levels in the tumor microenvironment, and their stimulation of specific TLRs can foster chronic inflammation. This review discusses how carcinogenesis, cancer progression, and site-specific metastasis are related to interactions between cancer cells, immune cells, and DAMPs through TLR activation in the tumor microenvironment.
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spelling pubmed-27563392009-10-07 Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment Sato, Yusuke Goto, Yasufumi Narita, Norihiko Hoon, Dave S.B. Cancer Microenviron Original Paper Toll-like receptors (TLRs) play a crucial role in the innate immune response and the subsequent induction of adaptive immune responses against microbial infection or tissue injury. Recent findings show that functional TLRs are expressed not only on immune cells but also on cancer cells. TLRs play an active role in carcinogenesis and tumor progression during chronic inflammation that involves the tumor microenvironment. Damage-associated molecular patterns (DAMPs) derived from injured normal epithelial cells and necrotic cancer cells appear to be present at significant levels in the tumor microenvironment, and their stimulation of specific TLRs can foster chronic inflammation. This review discusses how carcinogenesis, cancer progression, and site-specific metastasis are related to interactions between cancer cells, immune cells, and DAMPs through TLR activation in the tumor microenvironment. Springer Netherlands 2009-08-15 /pmc/articles/PMC2756339/ /pubmed/19685283 http://dx.doi.org/10.1007/s12307-009-0022-y Text en © Springer Science+Business Media B.V. 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Paper
Sato, Yusuke
Goto, Yasufumi
Narita, Norihiko
Hoon, Dave S.B.
Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment
title Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment
title_full Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment
title_fullStr Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment
title_full_unstemmed Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment
title_short Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment
title_sort cancer cells expressing toll-like receptors and the tumor microenvironment
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756339/
https://www.ncbi.nlm.nih.gov/pubmed/19685283
http://dx.doi.org/10.1007/s12307-009-0022-y
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AT naritanorihiko cancercellsexpressingtolllikereceptorsandthetumormicroenvironment
AT hoondavesb cancercellsexpressingtolllikereceptorsandthetumormicroenvironment

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