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Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats
Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical a...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756466/ https://www.ncbi.nlm.nih.gov/pubmed/19812703 http://dx.doi.org/10.1155/2009/329632 |
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author | Hernández-Fonseca, Juan P. Rincón, Jaimar Pedreañez, Adriana Viera, Ninoska Arcaya, José L. Carrizo, Edgardo Mosquera, Jesús |
author_facet | Hernández-Fonseca, Juan P. Rincón, Jaimar Pedreañez, Adriana Viera, Ninoska Arcaya, José L. Carrizo, Edgardo Mosquera, Jesús |
author_sort | Hernández-Fonseca, Juan P. |
collection | PubMed |
description | Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes. Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats. Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swollen axonal boutoms, fragmentation of neurofilaments, and oligodendrocyte abnormalities. In addition, depressive mood was observed in diabetic animals. The brain morphological alterations observed in diabetic animals could be related to brain pathologic process leading to abnormal function, cellular death, and depressive behavioral. |
format | Text |
id | pubmed-2756466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-27564662009-10-06 Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats Hernández-Fonseca, Juan P. Rincón, Jaimar Pedreañez, Adriana Viera, Ninoska Arcaya, José L. Carrizo, Edgardo Mosquera, Jesús Exp Diabetes Res Research Article Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes. Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats. Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swollen axonal boutoms, fragmentation of neurofilaments, and oligodendrocyte abnormalities. In addition, depressive mood was observed in diabetic animals. The brain morphological alterations observed in diabetic animals could be related to brain pathologic process leading to abnormal function, cellular death, and depressive behavioral. Hindawi Publishing Corporation 2009 2009-10-01 /pmc/articles/PMC2756466/ /pubmed/19812703 http://dx.doi.org/10.1155/2009/329632 Text en Copyright © 2009 Juan P. Hernández-Fonseca et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hernández-Fonseca, Juan P. Rincón, Jaimar Pedreañez, Adriana Viera, Ninoska Arcaya, José L. Carrizo, Edgardo Mosquera, Jesús Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats |
title | Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats |
title_full | Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats |
title_fullStr | Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats |
title_full_unstemmed | Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats |
title_short | Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats |
title_sort | structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756466/ https://www.ncbi.nlm.nih.gov/pubmed/19812703 http://dx.doi.org/10.1155/2009/329632 |
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