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Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats

Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical a...

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Autores principales: Hernández-Fonseca, Juan P., Rincón, Jaimar, Pedreañez, Adriana, Viera, Ninoska, Arcaya, José L., Carrizo, Edgardo, Mosquera, Jesús
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756466/
https://www.ncbi.nlm.nih.gov/pubmed/19812703
http://dx.doi.org/10.1155/2009/329632
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author Hernández-Fonseca, Juan P.
Rincón, Jaimar
Pedreañez, Adriana
Viera, Ninoska
Arcaya, José L.
Carrizo, Edgardo
Mosquera, Jesús
author_facet Hernández-Fonseca, Juan P.
Rincón, Jaimar
Pedreañez, Adriana
Viera, Ninoska
Arcaya, José L.
Carrizo, Edgardo
Mosquera, Jesús
author_sort Hernández-Fonseca, Juan P.
collection PubMed
description Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes. Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats. Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swollen axonal boutoms, fragmentation of neurofilaments, and oligodendrocyte abnormalities. In addition, depressive mood was observed in diabetic animals. The brain morphological alterations observed in diabetic animals could be related to brain pathologic process leading to abnormal function, cellular death, and depressive behavioral.
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spelling pubmed-27564662009-10-06 Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats Hernández-Fonseca, Juan P. Rincón, Jaimar Pedreañez, Adriana Viera, Ninoska Arcaya, José L. Carrizo, Edgardo Mosquera, Jesús Exp Diabetes Res Research Article Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes. Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats. Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swollen axonal boutoms, fragmentation of neurofilaments, and oligodendrocyte abnormalities. In addition, depressive mood was observed in diabetic animals. The brain morphological alterations observed in diabetic animals could be related to brain pathologic process leading to abnormal function, cellular death, and depressive behavioral. Hindawi Publishing Corporation 2009 2009-10-01 /pmc/articles/PMC2756466/ /pubmed/19812703 http://dx.doi.org/10.1155/2009/329632 Text en Copyright © 2009 Juan P. Hernández-Fonseca et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hernández-Fonseca, Juan P.
Rincón, Jaimar
Pedreañez, Adriana
Viera, Ninoska
Arcaya, José L.
Carrizo, Edgardo
Mosquera, Jesús
Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats
title Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats
title_full Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats
title_fullStr Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats
title_full_unstemmed Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats
title_short Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats
title_sort structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756466/
https://www.ncbi.nlm.nih.gov/pubmed/19812703
http://dx.doi.org/10.1155/2009/329632
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