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Vaccination with Mage-b DNA induces CD8 T-cell responses at young but not old age in mice with metastatic breast cancer

BACKGROUND: Elderly individuals react less efficiently to vaccines than do adults, mainly because of T-cell unresponsiveness. In this study, we analysed whether tumour-associated antigen (TAA)-specific CD8 T-cell responses could be induced by vaccination in old mice with metastatic breast cancer. ME...

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Detalles Bibliográficos
Autores principales:	Castro, F, Leal, B, Denny, A, Bahar, R, Lampkin, S, Reddick, R, Lu, S, Gravekamp, C
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2009
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756562/ https://www.ncbi.nlm.nih.gov/pubmed/19826426 http://dx.doi.org/10.1038/sj.bjc.6605329

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