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Nucleotide excision repair and recombination are engaged in repair of trans-4-hydroxy-2-nonenal adducts to DNA bases in Escherichia coli

One of the major products of lipid peroxidation is trans-4-hydroxy-2-nonenal (HNE). HNE forms highly mutagenic and genotoxic adducts to all DNA bases. Using M13 phage lacZ system, we studied the mutagenesis and repair of HNE treated phage DNA in E. coli wild-type or uvrA, recA, and mutL mutants. The...

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Detalles Bibliográficos
Autores principales:	Janowska, Beata, Komisarski, Marek, Prorok, Paulina, Sokołowska, Beata, Kuśmierek, Jarosław, Janion, Celina, Tudek, Barbara
Formato:	Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2009
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757579/ https://www.ncbi.nlm.nih.gov/pubmed/19834545

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