Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells

BACKGROUND: Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes. METHODOLOGY/PRINCIPAL FINDINGS:...

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Detalles Bibliográficos
Autores principales: Soh, Junichi, Okumura, Naoki, Lockwood, William W., Yamamoto, Hiromasa, Shigematsu, Hisayuki, Zhang, Wei, Chari, Raj, Shames, David S., Tang, Ximing, MacAulay, Calum, Varella-Garcia, Marileila, Vooder, Tõnu, Wistuba, Ignacio I., Lam, Stephen, Brekken, Rolf, Toyooka, Shinichi, Minna, John D., Lam, Wan L., Gazdar, Adi F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757721/
https://www.ncbi.nlm.nih.gov/pubmed/19826477
http://dx.doi.org/10.1371/journal.pone.0007464

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