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Inhibition of K(Ca)2.2 and K(Ca)2.3 channel currents by protonation of outer pore histidine residues

Ion channels are often modulated by changes in extracellular pH, with most examples resulting from shifts in the ionization state of histidine residue(s) in the channel pore. The application of acidic extracellular solution inhibited expressed K(Ca)2.2 (SK2) and K(Ca)2.3 (SK3) channel currents, with...

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Detalles Bibliográficos
Autores principales:	Goodchild, Samuel J., Lamy, Cedric, Seutin, Vincent, Marrion, Neil V.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757770/ https://www.ncbi.nlm.nih.gov/pubmed/19786583 http://dx.doi.org/10.1085/jgp.200910252

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