Letter to the editor: Does Dicer Expression Affect shRNA processing?

Elevated Dicer and Drosha mRNA levels have been documented across a range of tumor types (including ovarian carcinoma) by a number of investigators without any demonstrable correlation with patient survival nor evidence of interference with shRNA processing. A recent publication by Merritt et al. (N...

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Detalles Bibliográficos
Autores principales: Senzer, Neil, Rao, Donald, Nemunaitis, John
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2009
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758281/
https://www.ncbi.nlm.nih.gov/pubmed/19838337
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author Senzer, Neil
Rao, Donald
Nemunaitis, John
author_facet Senzer, Neil
Rao, Donald
Nemunaitis, John
author_sort Senzer, Neil
collection PubMed
description Elevated Dicer and Drosha mRNA levels have been documented across a range of tumor types (including ovarian carcinoma) by a number of investigators without any demonstrable correlation with patient survival nor evidence of interference with shRNA processing. A recent publication by Merritt et al. (NEJM 359(25):2641-50, 2008) reporting their findings in patients with ovarian carcinoma reach opposite conclusions. Further study will be needed to resolve this issue.
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spelling pubmed-27582812009-10-16 Letter to the editor: Does Dicer Expression Affect shRNA processing? Senzer, Neil Rao, Donald Nemunaitis, John Gene Regul Syst Bio Letter to the Editor Elevated Dicer and Drosha mRNA levels have been documented across a range of tumor types (including ovarian carcinoma) by a number of investigators without any demonstrable correlation with patient survival nor evidence of interference with shRNA processing. A recent publication by Merritt et al. (NEJM 359(25):2641-50, 2008) reporting their findings in patients with ovarian carcinoma reach opposite conclusions. Further study will be needed to resolve this issue. Libertas Academica 2009-06-19 /pmc/articles/PMC2758281/ /pubmed/19838337 Text en © the authors, licensee Libertas Academica Ltd. http://creativecommons.org/licenses/by/2.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/2.0/).
spellingShingle Letter to the Editor
Senzer, Neil
Rao, Donald
Nemunaitis, John
Letter to the editor: Does Dicer Expression Affect shRNA processing?
title Letter to the editor: Does Dicer Expression Affect shRNA processing?
title_full Letter to the editor: Does Dicer Expression Affect shRNA processing?
title_fullStr Letter to the editor: Does Dicer Expression Affect shRNA processing?
title_full_unstemmed Letter to the editor: Does Dicer Expression Affect shRNA processing?
title_short Letter to the editor: Does Dicer Expression Affect shRNA processing?
title_sort letter to the editor: does dicer expression affect shrna processing?
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758281/
https://www.ncbi.nlm.nih.gov/pubmed/19838337
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