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Artemisinins: their growing importance in medicine
Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis. More recently, they have...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Published By Elsevier In Association With The International Union Of Pharmacology
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758403/ https://www.ncbi.nlm.nih.gov/pubmed/18752857 http://dx.doi.org/10.1016/j.tips.2008.07.004 |
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author | Krishna, Sanjeev Bustamante, Leyla Haynes, Richard K. Staines, Henry M. |
author_facet | Krishna, Sanjeev Bustamante, Leyla Haynes, Richard K. Staines, Henry M. |
author_sort | Krishna, Sanjeev |
collection | PubMed |
description | Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis. More recently, they have also shown potent and broad anticancer properties in cell lines and animal models. In this review, we discuss recent advances in defining the role of artemisinins in medicine, with particular focus on their controversial mechanisms of action. This safe and cheap drug class that saves lives at risk from malaria can also have important potential in oncology. |
format | Text |
id | pubmed-2758403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Published By Elsevier In Association With The International Union Of Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-27584032009-10-23 Artemisinins: their growing importance in medicine Krishna, Sanjeev Bustamante, Leyla Haynes, Richard K. Staines, Henry M. Trends Pharmacol Sci Review Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains. Their efficacy also extends to phylogenetically unrelated parasitic infections such as schistosomiasis. More recently, they have also shown potent and broad anticancer properties in cell lines and animal models. In this review, we discuss recent advances in defining the role of artemisinins in medicine, with particular focus on their controversial mechanisms of action. This safe and cheap drug class that saves lives at risk from malaria can also have important potential in oncology. Published By Elsevier In Association With The International Union Of Pharmacology 2008-10 /pmc/articles/PMC2758403/ /pubmed/18752857 http://dx.doi.org/10.1016/j.tips.2008.07.004 Text en © 2008 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Review Krishna, Sanjeev Bustamante, Leyla Haynes, Richard K. Staines, Henry M. Artemisinins: their growing importance in medicine |
title | Artemisinins: their growing importance in medicine |
title_full | Artemisinins: their growing importance in medicine |
title_fullStr | Artemisinins: their growing importance in medicine |
title_full_unstemmed | Artemisinins: their growing importance in medicine |
title_short | Artemisinins: their growing importance in medicine |
title_sort | artemisinins: their growing importance in medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758403/ https://www.ncbi.nlm.nih.gov/pubmed/18752857 http://dx.doi.org/10.1016/j.tips.2008.07.004 |
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