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Association between different levels of dysglycemia and metabolic syndrome in pregnancy

BACKGROUND: In this study, we sought to evaluate the prevalence of metabolic syndrome (MS) in a cohort of pregnant women with a wide range of glucose tolerance, prepregnancy risk factors for MS during pregnancy, and the effects of MS in the outcomes in the mother and in the newborn. METHODS: One hun...

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Autores principales: Negrato, Carlos A, Jovanovic, Lois, Rafacho, Alex, Tambascia, Marcos A, Geloneze, Bruno, Dias, Adriano, Rudge, Marilza VC
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758580/
https://www.ncbi.nlm.nih.gov/pubmed/19825195
http://dx.doi.org/10.1186/1758-5996-1-3
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author Negrato, Carlos A
Jovanovic, Lois
Rafacho, Alex
Tambascia, Marcos A
Geloneze, Bruno
Dias, Adriano
Rudge, Marilza VC
author_facet Negrato, Carlos A
Jovanovic, Lois
Rafacho, Alex
Tambascia, Marcos A
Geloneze, Bruno
Dias, Adriano
Rudge, Marilza VC
author_sort Negrato, Carlos A
collection PubMed
description BACKGROUND: In this study, we sought to evaluate the prevalence of metabolic syndrome (MS) in a cohort of pregnant women with a wide range of glucose tolerance, prepregnancy risk factors for MS during pregnancy, and the effects of MS in the outcomes in the mother and in the newborn. METHODS: One hundred and thirty six women with positive screening for gestational diabetes mellitus (GDM) were classified by two diagnostic methods: glycemic profile and 100 g OGTT as normoglycemic, mild gestational hyperglycemic, GDM, and overt GDM. Markers of MS were measured between 24-28(th )during the screening. RESULTS: The prevalence of MS was: 0%; 20.0%; 23.5% and 36.4% in normoglycemic, mild hyperglycemic, GDM, and overt GDM groups, respectively. Previous history of GDM with or without insulin use, BMI ≥ 25, hypertension, family history of diabetes in first degree relatives, non-Caucasian ethnicity, history of prematurity and polihydramnios were statistically significant prepregnancy predictors for MS in the index pregnancy, that by its turn increased the adverse outcomes in the mother and in the newborn. CONCLUSION: The prevalence of MS increases with the worsening of glucose tolerance; impaired glycemic profile identifies pregnancies with important metabolic abnormalities even in the presence of a normal OGTT, in patients that are not classified as having GDM.
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spelling pubmed-27585802009-10-08 Association between different levels of dysglycemia and metabolic syndrome in pregnancy Negrato, Carlos A Jovanovic, Lois Rafacho, Alex Tambascia, Marcos A Geloneze, Bruno Dias, Adriano Rudge, Marilza VC Diabetol Metab Syndr Research BACKGROUND: In this study, we sought to evaluate the prevalence of metabolic syndrome (MS) in a cohort of pregnant women with a wide range of glucose tolerance, prepregnancy risk factors for MS during pregnancy, and the effects of MS in the outcomes in the mother and in the newborn. METHODS: One hundred and thirty six women with positive screening for gestational diabetes mellitus (GDM) were classified by two diagnostic methods: glycemic profile and 100 g OGTT as normoglycemic, mild gestational hyperglycemic, GDM, and overt GDM. Markers of MS were measured between 24-28(th )during the screening. RESULTS: The prevalence of MS was: 0%; 20.0%; 23.5% and 36.4% in normoglycemic, mild hyperglycemic, GDM, and overt GDM groups, respectively. Previous history of GDM with or without insulin use, BMI ≥ 25, hypertension, family history of diabetes in first degree relatives, non-Caucasian ethnicity, history of prematurity and polihydramnios were statistically significant prepregnancy predictors for MS in the index pregnancy, that by its turn increased the adverse outcomes in the mother and in the newborn. CONCLUSION: The prevalence of MS increases with the worsening of glucose tolerance; impaired glycemic profile identifies pregnancies with important metabolic abnormalities even in the presence of a normal OGTT, in patients that are not classified as having GDM. BioMed Central 2009-08-26 /pmc/articles/PMC2758580/ /pubmed/19825195 http://dx.doi.org/10.1186/1758-5996-1-3 Text en Copyright © 2009 Negrato et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Negrato, Carlos A
Jovanovic, Lois
Rafacho, Alex
Tambascia, Marcos A
Geloneze, Bruno
Dias, Adriano
Rudge, Marilza VC
Association between different levels of dysglycemia and metabolic syndrome in pregnancy
title Association between different levels of dysglycemia and metabolic syndrome in pregnancy
title_full Association between different levels of dysglycemia and metabolic syndrome in pregnancy
title_fullStr Association between different levels of dysglycemia and metabolic syndrome in pregnancy
title_full_unstemmed Association between different levels of dysglycemia and metabolic syndrome in pregnancy
title_short Association between different levels of dysglycemia and metabolic syndrome in pregnancy
title_sort association between different levels of dysglycemia and metabolic syndrome in pregnancy
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758580/
https://www.ncbi.nlm.nih.gov/pubmed/19825195
http://dx.doi.org/10.1186/1758-5996-1-3
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