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NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events
We present a non-parametric and computationally efficient method named NeuroXidence that detects coordinated firing of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance. The method considers the full auto-structure...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer US
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758673/ https://www.ncbi.nlm.nih.gov/pubmed/18219568 http://dx.doi.org/10.1007/s10827-007-0065-3 |
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author | Pipa, Gordon Wheeler, Diek W. Singer, Wolf Nikolić, Danko |
author_facet | Pipa, Gordon Wheeler, Diek W. Singer, Wolf Nikolić, Danko |
author_sort | Pipa, Gordon |
collection | PubMed |
description | We present a non-parametric and computationally efficient method named NeuroXidence that detects coordinated firing of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance. The method considers the full auto-structure of the data, including the changes in the rate responses and the history dependencies in the spiking activity. Also, the method accounts for trial-by-trial variability in the dataset, such as the variability of the rate responses and their latencies. NeuroXidence can be applied to short data windows lasting only tens of milliseconds, which enables the tracking of transient neuronal states correlated to information processing. We demonstrate, on both simulated data and single-unit activity recorded in cat visual cortex, that NeuroXidence discriminates reliably between significant and spurious events that occur by chance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10827-007-0065-3) contains supplementary material, which is available to authorized users. |
format | Text |
id | pubmed-2758673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-27586732009-10-07 NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events Pipa, Gordon Wheeler, Diek W. Singer, Wolf Nikolić, Danko J Comput Neurosci Article We present a non-parametric and computationally efficient method named NeuroXidence that detects coordinated firing of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance. The method considers the full auto-structure of the data, including the changes in the rate responses and the history dependencies in the spiking activity. Also, the method accounts for trial-by-trial variability in the dataset, such as the variability of the rate responses and their latencies. NeuroXidence can be applied to short data windows lasting only tens of milliseconds, which enables the tracking of transient neuronal states correlated to information processing. We demonstrate, on both simulated data and single-unit activity recorded in cat visual cortex, that NeuroXidence discriminates reliably between significant and spurious events that occur by chance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10827-007-0065-3) contains supplementary material, which is available to authorized users. Springer US 2008-01-26 2008-08 /pmc/articles/PMC2758673/ /pubmed/18219568 http://dx.doi.org/10.1007/s10827-007-0065-3 Text en © Springer Science+Business Media, LLC 2007 |
spellingShingle | Article Pipa, Gordon Wheeler, Diek W. Singer, Wolf Nikolić, Danko NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events |
title | NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events |
title_full | NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events |
title_fullStr | NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events |
title_full_unstemmed | NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events |
title_short | NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events |
title_sort | neuroxidence: reliable and efficient analysis of an excess or deficiency of joint-spike events |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758673/ https://www.ncbi.nlm.nih.gov/pubmed/18219568 http://dx.doi.org/10.1007/s10827-007-0065-3 |
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