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NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events

We present a non-parametric and computationally efficient method named NeuroXidence that detects coordinated firing of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance. The method considers the full auto-structure...

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Detalles Bibliográficos
Autores principales: Pipa, Gordon, Wheeler, Diek W., Singer, Wolf, Nikolić, Danko
Formato: Texto
Lenguaje:English
Publicado: Springer US 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758673/
https://www.ncbi.nlm.nih.gov/pubmed/18219568
http://dx.doi.org/10.1007/s10827-007-0065-3
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author Pipa, Gordon
Wheeler, Diek W.
Singer, Wolf
Nikolić, Danko
author_facet Pipa, Gordon
Wheeler, Diek W.
Singer, Wolf
Nikolić, Danko
author_sort Pipa, Gordon
collection PubMed
description We present a non-parametric and computationally efficient method named NeuroXidence that detects coordinated firing of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance. The method considers the full auto-structure of the data, including the changes in the rate responses and the history dependencies in the spiking activity. Also, the method accounts for trial-by-trial variability in the dataset, such as the variability of the rate responses and their latencies. NeuroXidence can be applied to short data windows lasting only tens of milliseconds, which enables the tracking of transient neuronal states correlated to information processing. We demonstrate, on both simulated data and single-unit activity recorded in cat visual cortex, that NeuroXidence discriminates reliably between significant and spurious events that occur by chance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10827-007-0065-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-27586732009-10-07 NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events Pipa, Gordon Wheeler, Diek W. Singer, Wolf Nikolić, Danko J Comput Neurosci Article We present a non-parametric and computationally efficient method named NeuroXidence that detects coordinated firing of two or more neurons and tests whether the observed level of coordinated firing is significantly different from that expected by chance. The method considers the full auto-structure of the data, including the changes in the rate responses and the history dependencies in the spiking activity. Also, the method accounts for trial-by-trial variability in the dataset, such as the variability of the rate responses and their latencies. NeuroXidence can be applied to short data windows lasting only tens of milliseconds, which enables the tracking of transient neuronal states correlated to information processing. We demonstrate, on both simulated data and single-unit activity recorded in cat visual cortex, that NeuroXidence discriminates reliably between significant and spurious events that occur by chance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10827-007-0065-3) contains supplementary material, which is available to authorized users. Springer US 2008-01-26 2008-08 /pmc/articles/PMC2758673/ /pubmed/18219568 http://dx.doi.org/10.1007/s10827-007-0065-3 Text en © Springer Science+Business Media, LLC 2007
spellingShingle Article
Pipa, Gordon
Wheeler, Diek W.
Singer, Wolf
Nikolić, Danko
NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events
title NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events
title_full NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events
title_fullStr NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events
title_full_unstemmed NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events
title_short NeuroXidence: reliable and efficient analysis of an excess or deficiency of joint-spike events
title_sort neuroxidence: reliable and efficient analysis of an excess or deficiency of joint-spike events
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758673/
https://www.ncbi.nlm.nih.gov/pubmed/18219568
http://dx.doi.org/10.1007/s10827-007-0065-3
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