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Practical Lessons from Theoretical Models about the Somitogenesis

Vertebrae and other mammalian repetitive structures are formed from embryonic organs called somites. Somites arise sequentially from the unsegmented presomitic mesoderm (PSM). In mice, a new bilateral pair of somites arise every two hours from the rostral PSM. On the other hand, cells are added to t...

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Detalles Bibliográficos
Autores principales: González, Aitor, Kageyama, Ryoichiro
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759138/
https://www.ncbi.nlm.nih.gov/pubmed/19936076
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author González, Aitor
Kageyama, Ryoichiro
author_facet González, Aitor
Kageyama, Ryoichiro
author_sort González, Aitor
collection PubMed
description Vertebrae and other mammalian repetitive structures are formed from embryonic organs called somites. Somites arise sequentially from the unsegmented presomitic mesoderm (PSM). In mice, a new bilateral pair of somites arise every two hours from the rostral PSM. On the other hand, cells are added to the caudal side of the PSM due to cell proliferation of the tail bud. Somite formation correlates with cycles of cell-autonomous expression in the PSM of genes like Hes7. Because the somitogenesis is a highly dynamic and coordinated process, this event has been subjected to extensive theoretical modeling. Here, we describe the current understanding about the somitogenesis in mouse embryos with an emphasis on insights gained from computer simulations. It is worth noting that the combination of experiments and computer simulations has uncovered dynamical properties of the somitogenesis clock such as the transcription/translation delays, the half-life and the synchronization mechanism across the PSM. Theoretical models have also been useful to provide predictions and rigorous hypothesis about poorly understood processes such as the mechanisms by which the temporal PSM oscillations are arrested and converted into an spatial pattern. We aim at reviewing this theoretical literature in such a way that experimentalists might appreciate the resulting conclusions.
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spelling pubmed-27591382009-11-23 Practical Lessons from Theoretical Models about the Somitogenesis González, Aitor Kageyama, Ryoichiro Gene Regul Syst Bio Review Vertebrae and other mammalian repetitive structures are formed from embryonic organs called somites. Somites arise sequentially from the unsegmented presomitic mesoderm (PSM). In mice, a new bilateral pair of somites arise every two hours from the rostral PSM. On the other hand, cells are added to the caudal side of the PSM due to cell proliferation of the tail bud. Somite formation correlates with cycles of cell-autonomous expression in the PSM of genes like Hes7. Because the somitogenesis is a highly dynamic and coordinated process, this event has been subjected to extensive theoretical modeling. Here, we describe the current understanding about the somitogenesis in mouse embryos with an emphasis on insights gained from computer simulations. It is worth noting that the combination of experiments and computer simulations has uncovered dynamical properties of the somitogenesis clock such as the transcription/translation delays, the half-life and the synchronization mechanism across the PSM. Theoretical models have also been useful to provide predictions and rigorous hypothesis about poorly understood processes such as the mechanisms by which the temporal PSM oscillations are arrested and converted into an spatial pattern. We aim at reviewing this theoretical literature in such a way that experimentalists might appreciate the resulting conclusions. Libertas Academica 2007-05-28 /pmc/articles/PMC2759138/ /pubmed/19936076 Text en © 2007 The authors. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
González, Aitor
Kageyama, Ryoichiro
Practical Lessons from Theoretical Models about the Somitogenesis
title Practical Lessons from Theoretical Models about the Somitogenesis
title_full Practical Lessons from Theoretical Models about the Somitogenesis
title_fullStr Practical Lessons from Theoretical Models about the Somitogenesis
title_full_unstemmed Practical Lessons from Theoretical Models about the Somitogenesis
title_short Practical Lessons from Theoretical Models about the Somitogenesis
title_sort practical lessons from theoretical models about the somitogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759138/
https://www.ncbi.nlm.nih.gov/pubmed/19936076
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