Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis

The bacterial PorB porin, an ATP-binding β-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial membrane potential (ΔΨ(m)). Here, we show that P...

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Detalles Bibliográficos
Autores principales: Kozjak-Pavlovic, Vera, Dian-Lothrop, Elke A., Meinecke, Michael, Kepp, Oliver, Ross, Katharina, Rajalingam, Krishnaraj, Harsman, Anke, Hauf, Eva, Brinkmann, Volker, Günther, Dirk, Herrmann, Ines, Hurwitz, Robert, Rassow, Joachim, Wagner, Richard, Rudel, Thomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759283/
https://www.ncbi.nlm.nih.gov/pubmed/19851451
http://dx.doi.org/10.1371/journal.ppat.1000629

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