Inhibition of cAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses toward Morphine- and Morphine Withdrawal-related Cues

To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner...

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Detalles Bibliográficos
Autores principales: Sanchis-Segura, Carles, Jancic, Dragana, Jimenez-Minchan, Maria, Barco, Angel
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2009
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759365/
https://www.ncbi.nlm.nih.gov/pubmed/19826619
http://dx.doi.org/10.3389/neuro.08.030.2009
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author Sanchis-Segura, Carles
Jancic, Dragana
Jimenez-Minchan, Maria
Barco, Angel
author_facet Sanchis-Segura, Carles
Jancic, Dragana
Jimenez-Minchan, Maria
Barco, Angel
author_sort Sanchis-Segura, Carles
collection PubMed
description To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues.
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spelling pubmed-27593652009-10-13 Inhibition of cAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses toward Morphine- and Morphine Withdrawal-related Cues Sanchis-Segura, Carles Jancic, Dragana Jimenez-Minchan, Maria Barco, Angel Front Behav Neurosci Neuroscience To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues. Frontiers Research Foundation 2009-09-08 /pmc/articles/PMC2759365/ /pubmed/19826619 http://dx.doi.org/10.3389/neuro.08.030.2009 Text en Copyright © 2009 Sanchis-Segura, Jancic, Jimenez-Minchan and Barco. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Sanchis-Segura, Carles
Jancic, Dragana
Jimenez-Minchan, Maria
Barco, Angel
Inhibition of cAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses toward Morphine- and Morphine Withdrawal-related Cues
title Inhibition of cAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses toward Morphine- and Morphine Withdrawal-related Cues
title_full Inhibition of cAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses toward Morphine- and Morphine Withdrawal-related Cues
title_fullStr Inhibition of cAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses toward Morphine- and Morphine Withdrawal-related Cues
title_full_unstemmed Inhibition of cAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses toward Morphine- and Morphine Withdrawal-related Cues
title_short Inhibition of cAMP Responsive Element Binding Protein in Striatal Neurons Enhances Approach and Avoidance Responses toward Morphine- and Morphine Withdrawal-related Cues
title_sort inhibition of camp responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759365/
https://www.ncbi.nlm.nih.gov/pubmed/19826619
http://dx.doi.org/10.3389/neuro.08.030.2009
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