Human cellular restriction factors that target HIV-1 replication

Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite mot...

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Detalles Bibliográficos
Autores principales: Strebel, Klaus, Luban, Jeremy, Jeang, Kuan-Teh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759957/
https://www.ncbi.nlm.nih.gov/pubmed/19758442
http://dx.doi.org/10.1186/1741-7015-7-48
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author Strebel, Klaus
Luban, Jeremy
Jeang, Kuan-Teh
author_facet Strebel, Klaus
Luban, Jeremy
Jeang, Kuan-Teh
author_sort Strebel, Klaus
collection PubMed
description Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.
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spelling pubmed-27599572009-10-11 Human cellular restriction factors that target HIV-1 replication Strebel, Klaus Luban, Jeremy Jeang, Kuan-Teh BMC Med Minireview Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions. BioMed Central 2009-09-16 /pmc/articles/PMC2759957/ /pubmed/19758442 http://dx.doi.org/10.1186/1741-7015-7-48 Text en Copyright © 2009 Strebel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireview
Strebel, Klaus
Luban, Jeremy
Jeang, Kuan-Teh
Human cellular restriction factors that target HIV-1 replication
title Human cellular restriction factors that target HIV-1 replication
title_full Human cellular restriction factors that target HIV-1 replication
title_fullStr Human cellular restriction factors that target HIV-1 replication
title_full_unstemmed Human cellular restriction factors that target HIV-1 replication
title_short Human cellular restriction factors that target HIV-1 replication
title_sort human cellular restriction factors that target hiv-1 replication
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759957/
https://www.ncbi.nlm.nih.gov/pubmed/19758442
http://dx.doi.org/10.1186/1741-7015-7-48
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AT jeangkuanteh humancellularrestrictionfactorsthattargethiv1replication

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