Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin

Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL(2)(H(2)O)(2)] ⋅ nH(2)O (1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in...

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Autores principales: Tan, Mingxiong, Zhu, Jinchan, Pan, Yingming, Chen, Zhenfeng, Liang, Hong, Liu, Huagang, Wang, Hengshan
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760321/
https://www.ncbi.nlm.nih.gov/pubmed/19830248
http://dx.doi.org/10.1155/2009/347872
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author Tan, Mingxiong
Zhu, Jinchan
Pan, Yingming
Chen, Zhenfeng
Liang, Hong
Liu, Huagang
Wang, Hengshan
author_facet Tan, Mingxiong
Zhu, Jinchan
Pan, Yingming
Chen, Zhenfeng
Liang, Hong
Liu, Huagang
Wang, Hengshan
author_sort Tan, Mingxiong
collection PubMed
description Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL(2)(H(2)O)(2)] ⋅ nH(2)O (1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively. The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD spectra. Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand.
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spelling pubmed-27603212009-10-14 Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin Tan, Mingxiong Zhu, Jinchan Pan, Yingming Chen, Zhenfeng Liang, Hong Liu, Huagang Wang, Hengshan Bioinorg Chem Appl Research Article Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL(2)(H(2)O)(2)] ⋅ nH(2)O (1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively. The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD spectra. Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand. Hindawi Publishing Corporation 2009 2009-10-08 /pmc/articles/PMC2760321/ /pubmed/19830248 http://dx.doi.org/10.1155/2009/347872 Text en Copyright © 2009 Mingxiong Tan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tan, Mingxiong
Zhu, Jinchan
Pan, Yingming
Chen, Zhenfeng
Liang, Hong
Liu, Huagang
Wang, Hengshan
Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
title Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
title_full Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
title_fullStr Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
title_full_unstemmed Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
title_short Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
title_sort synthesis, cytotoxic activity, and dna binding properties of copper (ii) complexes with hesperetin, naringenin, and apigenin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760321/
https://www.ncbi.nlm.nih.gov/pubmed/19830248
http://dx.doi.org/10.1155/2009/347872
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