A Statistical Model of Protein Sequence Similarity and Function Similarity Reveals Overly-Specific Function Predictions

BACKGROUND: Predicting protein function from primary sequence is an important open problem in modern biology. Not only are there many thousands of proteins of unknown function, current approaches for predicting function must be improved upon. One problem in particular is overly-specific function pre...

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Detalles Bibliográficos
Autores principales: Louie, Brenton, Higdon, Roger, Kolker, Eugene
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760442/
https://www.ncbi.nlm.nih.gov/pubmed/19844580
http://dx.doi.org/10.1371/journal.pone.0007546

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