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scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

BACKGROUND: Metastatic neoplasias are characterized by excessive cell proliferation and disruptions to apico-basal cell polarity and tissue architecture. Understanding how alterations in cell polarity can impact upon tumour development is, therefore, a central issue in cancer biology. The Drosophila...

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Detalles Bibliográficos
Autores principales:	Leong, Gregory R, Goulding, Karen R, Amin, Nancy, Richardson, Helena E, Brumby, Anthony M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760524/ https://www.ncbi.nlm.nih.gov/pubmed/19778415 http://dx.doi.org/10.1186/1741-7007-7-62

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