Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

Sequence-specific endonucleases recognizing long target sequences are emerging as powerful tools for genome engineering. These endonucleases could be used to correct deleterious mutations or to inactivate viruses, in a new approach to molecular medicine. However, such applications are highly demandi...

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Detalles Bibliográficos
Autores principales: Grizot, Sylvestre, Smith, Julianne, Daboussi, Fayza, Prieto, Jesús, Redondo, Pilar, Merino, Nekane, Villate, Maider, Thomas, Séverine, Lemaire, Laetitia, Montoya, Guillermo, Blanco, Francisco J., Pâques, Frédéric, Duchateau, Philippe
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760784/
https://www.ncbi.nlm.nih.gov/pubmed/19584299
http://dx.doi.org/10.1093/nar/gkp548

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