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In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form
To understand how underwinding and overwinding the DNA helix affects its structure, we simulated 19 independent DNA systems with fixed degrees of twist using molecular dynamics in a system that does not allow writhe. Underwinding DNA induced spontaneous, sequence-dependent base flipping and local de...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760789/ https://www.ncbi.nlm.nih.gov/pubmed/19586933 http://dx.doi.org/10.1093/nar/gkp556 |