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The role of deadenylation in the degradation of unstable mRNAs in trypanosomes

Removal of the poly(A) tail is the first step in the degradation of many eukaryotic mRNAs. In metazoans and yeast, the Ccr4/Caf1/Not complex has the predominant deadenylase activity, while the Pan2/Pan3 complex may trim poly(A) tails to the correct size, or initiate deadenylation. In trypanosomes, t...

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Detalles Bibliográficos
Autores principales:	Schwede, Angela, Manful, Theresa, Jha, Bhaskar Anand, Helbig, Claudia, Bercovich, Natalia, Stewart, Mhairi, Clayton, Christine
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760810/ https://www.ncbi.nlm.nih.gov/pubmed/19596809 http://dx.doi.org/10.1093/nar/gkp571

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