Conserved functional domains and a novel tertiary interaction near the pseudoknot drive translational activity of hepatitis C virus and hepatitis C virus-like internal ribosome entry sites

The translational activity of the hepatitis C virus (HCV) internal ribosome entry site (IRES) and other HCV-like IRES RNAs depends on structured RNA elements in domains II and III, which serve to recruit the ribosomal 40S subunit, eukaryotic initiation factor (eIF) 3 and the ternary eIF2/Met-tRNA(i)...

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Detalles Bibliográficos
Autores principales: Easton, Laura E., Locker, Nicolas, Lukavsky, Peter J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760816/
https://www.ncbi.nlm.nih.gov/pubmed/19596815
http://dx.doi.org/10.1093/nar/gkp588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760816/
https://www.ncbi.nlm.nih.gov/pubmed/19596815
http://dx.doi.org/10.1093/nar/gkp588

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