Cargando…
Identification of novel host-oriented targets for Human Immunodeficiency Virus type 1 using Random Homozygous Gene Perturbation
BACKGROUND: Human Immunodeficiency Virus (HIV) is a global threat to public health. Current therapies that directly target the virus often are rendered ineffective due to the emergence of drug-resistant viral variants. An emerging concept to combat drug resistance is the idea of targeting host mecha...
Autores principales: | Mao, Hanwen, Chen, Hanson, Fesseha, Zena, Chang, Shaojing, Ung-Medoff, Huong, Van Dyke, Jessica, Kohli, Manu, Li, Wu-Bo, Goldblatt, Michael, Kinch, Michael S |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760863/ https://www.ncbi.nlm.nih.gov/pubmed/19788744 http://dx.doi.org/10.1186/1743-422X-6-154 |
Ejemplares similares
-
Immunodeficiency and disseminated mycobacterial infection associated with homozygous nonsense mutation of IKKβ()
por: Burns, Siobhan O., et al.
Publicado: (2014) -
The Landscape of Host Transcriptional Response Programs Commonly Perturbed by Bacterial Pathogens: Towards Host-Oriented Broad-Spectrum Drug Targets
por: Kidane, Yared H., et al.
Publicado: (2013) -
A Novel Homozygous Mutation Destabilizes IKKβ and Leads to Human Combined Immunodeficiency
por: Qin, Tao, et al.
Publicado: (2021) -
LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation
por: Zinngrebe, Julia, et al.
Publicado: (2016) -
Megalobastic anemia, infantile leukemia, and immunodeficiency caused by a novel homozygous mutation in the DHFR gene
por: Kuijpers, Taco W., et al.
Publicado: (2022)