Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

BACKGROUND: Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy neuroblastomas, elevated MYCN mRNA and protein levels are paradoxically associated with a more favorable cli...

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Detalles Bibliográficos
Autores principales: Westermann, Frank, Muth, Daniel, Benner, Axel, Bauer, Tobias, Henrich, Kai-Oliver, Oberthuer, André, Brors, Benedikt, Beissbarth, Tim, Vandesompele, Jo, Pattyn, Filip, Hero, Barbara, König, Rainer, Fischer, Matthias, Schwab, Manfred
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760877/
https://www.ncbi.nlm.nih.gov/pubmed/18851746
http://dx.doi.org/10.1186/gb-2008-9-10-r150

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