Extracellular Redox Modulation by Regulatory T Cells(†)

We demonstrate that the mechanism of redox remodeling during mouse T cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes...

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Detalles Bibliográficos
Autores principales: Yan, Zhonghua, Garg, Sanjay K, Kipnis, Jonathan, Banerjee, Ruma
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760945/
https://www.ncbi.nlm.nih.gov/pubmed/19718041
http://dx.doi.org/10.1038/nchembio.212
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author Yan, Zhonghua
Garg, Sanjay K
Kipnis, Jonathan
Banerjee, Ruma
author_facet Yan, Zhonghua
Garg, Sanjay K
Kipnis, Jonathan
Banerjee, Ruma
author_sort Yan, Zhonghua
collection PubMed
description We demonstrate that the mechanism of redox remodeling during mouse T cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite-signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.
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spelling pubmed-27609452010-04-01 Extracellular Redox Modulation by Regulatory T Cells(†) Yan, Zhonghua Garg, Sanjay K Kipnis, Jonathan Banerjee, Ruma Nat Chem Biol Article We demonstrate that the mechanism of redox remodeling during mouse T cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite-signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells. 2009-08-30 2009-10 /pmc/articles/PMC2760945/ /pubmed/19718041 http://dx.doi.org/10.1038/nchembio.212 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Yan, Zhonghua
Garg, Sanjay K
Kipnis, Jonathan
Banerjee, Ruma
Extracellular Redox Modulation by Regulatory T Cells(†)
title Extracellular Redox Modulation by Regulatory T Cells(†)
title_full Extracellular Redox Modulation by Regulatory T Cells(†)
title_fullStr Extracellular Redox Modulation by Regulatory T Cells(†)
title_full_unstemmed Extracellular Redox Modulation by Regulatory T Cells(†)
title_short Extracellular Redox Modulation by Regulatory T Cells(†)
title_sort extracellular redox modulation by regulatory t cells(†)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760945/
https://www.ncbi.nlm.nih.gov/pubmed/19718041
http://dx.doi.org/10.1038/nchembio.212
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AT gargsanjayk extracellularredoxmodulationbyregulatorytcells
AT kipnisjonathan extracellularredoxmodulationbyregulatorytcells
AT banerjeeruma extracellularredoxmodulationbyregulatorytcells

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