Surface activity of surfactant spiked with vitamin A

BACKGROUND: Intramuscular injections of vitamin A decrease the risk of broncho-pulmonary dysplasia. Admixture of vitamin A with surfactant as a lipophilic vehicle might be a less invasive modality. AIM: Test physical properties of surfactant + vitamin A. METHODS: Miscibility and surface activity wer...

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Detalles Bibliográficos
Autores principales: Bronshtein, Vadim, Venkatesh, Vugranam, Aulakh, Jas, Chessex, Philippe
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761185/
https://www.ncbi.nlm.nih.gov/pubmed/19920902
Descripción
Sumario:BACKGROUND: Intramuscular injections of vitamin A decrease the risk of broncho-pulmonary dysplasia. Admixture of vitamin A with surfactant as a lipophilic vehicle might be a less invasive modality. AIM: Test physical properties of surfactant + vitamin A. METHODS: Miscibility and surface activity were tested in surfactant supplemented with retinyl-acetate, -palmitate, 13-cis-, or all-trans-retinoic acid. RESULTS: Retinol acetate (5000 IU/mL) demonstrated miscibility with surfactant when premixing with ethanol. Its surface activity was 40% lower compared to surfactant alone. CONCLUSION: These findings warrant preclinical studies to test whether administration of vitamin A in subjects requiring surfactant is associated with beneficial functional properties.

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