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Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide

AIMS: Our objective was to investigate whether pro-oxidant properties of ascorbic acid (AA) and tetrahydrobiopterin (BH(4)) modulate endothelium-dependent, electrotonically mediated arterial relaxation. METHODS AND RESULTS: In studies with rabbit iliac artery (RIA) rings, NO-independent, endothelium...

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Detalles Bibliográficos
Autores principales:	Garry, Ambroise, Edwards, David H., Fallis, Ian F., Jenkins, Robert L., Griffith, Tudor M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761203/ https://www.ncbi.nlm.nih.gov/pubmed/19592567 http://dx.doi.org/10.1093/cvr/cvp235

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