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Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease
Homologous recombination (HR) is a highly accurate mechanism of DNA repair that can be exploited for homology-directed gene targeting. Since in most cell types HR occurs very infrequently (∼10(−6) to 10(−8)), its practical application has been largely restricted to specific experimental systems that...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761290/ https://www.ncbi.nlm.nih.gov/pubmed/19651880 http://dx.doi.org/10.1093/nar/gkp643 |