Cargando…

Mapping of HNF4α target genes in intestinal epithelial cells

BACKGROUND: The role of HNF4α has been extensively studied in hepatocytes and pancreatic β-cells, and HNF4α is also regarded as a key regulator of intestinal epithelial cell differentiation. The aim of the present work is to identify novel HNF4α target genes in the human intestinal epithelial cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boyd, Mette, Bressendorff, Simon, Møller, Jette, Olsen, Jørgen, Troelsen, Jesper T
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761415/ https://www.ncbi.nlm.nih.gov/pubmed/19761587 http://dx.doi.org/10.1186/1471-230X-9-68

Ejemplares similares

HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity
por: Larsen, Sylvester, et al.
Publicado: (2019)

Identification of TNF-α-Responsive Promoters and Enhancers in the Intestinal Epithelial Cell Model Caco-2
por: Boyd, Mette, et al.
Publicado: (2014)

Crystallization of hepatocyte nuclear factor 4α (HNF4α) in complex with the HNF1α promoter element
por: Lu, Peng, et al.
Publicado: (2008)

Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
por: Teeli, Aamir Salam, et al.
Publicado: (2021)

Functional Targets of the Monogenic Diabetes Transcription Factors HNF-1α and HNF-4α Are Highly Conserved Between Mice and Humans
por: Boj, Sylvia F., et al.
Publicado: (2009)

A Novel Organoid Model of Damage and Repair Identifies HNF4α as a Critical Regulator of Intestinal Epithelial Regeneration
por: Montenegro-Miranda, Paula S., et al.
Publicado: (2020)

Epistasis of Transcriptomes Reveals Synergism between Transcriptional Activators Hnf1α and Hnf4α
por: Boj, Sylvia F., et al.
Publicado: (2010)

LncRNA Hnf4αos exacerbates liver ischemia/reperfusion injury in mice via Hnf4αos/Hnf4α duplex-mediated PGC1α suppression
por: Wang, Chaoqun, et al.
Publicado: (2022)

HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide
por: Girard, Romain, et al.
Publicado: (2019)

HOXB4 Gene Expression Is Regulated by CDX2 in Intestinal Epithelial Cells
por: Jørgensen, Steffen, et al.
Publicado: (2016)

YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation
por: Noce, Valeria, et al.
Publicado: (2019)

Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation
por: Wang, Ping, et al.
Publicado: (2017)

Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist
por: Lee, Seung-Hee, et al.
Publicado: (2021)

The protein architecture and allosteric landscape of HNF4α
por: Rastinejad, Fraydoon
Publicado: (2023)

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
por: Sang, Lei, et al.
Publicado: (2022)

The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases
por: Chen, Liming, et al.
Publicado: (2020)

A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells
por: Lee, Seung-Hee, et al.
Publicado: (2022)

HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate
por: Jones, Christine, et al.
Publicado: (2022)

Functional inhibition of Oct leads to HNF4α upregulation
por: Vollmar, Johanna, et al.
Publicado: (2021)

HNF4α is possibly the missing link between epithelial–mesenchymal transition and Warburg effect during hepatocarcinogenesis
por: Shokouhian, Bahare, et al.
Publicado: (2022)

SAT-162 Hepatocyte Nuclear Factor-4α (HNF44α) as a Target to Treat DM
por: Jorge dos Santos, Gustavo, et al.
Publicado: (2019)

Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestine
por: Vemuri, Kiranmayi, et al.
Publicado: (2023)

Neddylation inhibitor MLN4924 has anti‐HBV activity via modulating the ERK‐HNF1α‐C/EBPα‐HNF4α axis
por: Xie, Mingjie, et al.
Publicado: (2020)

Saikosaponin C exerts anti-HBV effects by attenuating HNF1α and HNF4α expression to suppress HBV pgRNA synthesis
por: Pan, Yanchao, et al.
Publicado: (2019)

TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression
por: Ni, Zhen, et al.
Publicado: (2020)

Role of PPARα and HNF4α in Stress-Mediated Alterations in Lipid Homeostasis
por: Konstandi, Maria, et al.
Publicado: (2013)

SUMOylation of HNF4α regulates protein stability and hepatocyte function
por: Zhou, Wenli, et al.
Publicado: (2012)

The hepatic lipidome and HNF4α and SHBG expression in human liver
por: Winters, Stephen J, et al.
Publicado: (2020)

Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics
por: Meijer, Isabelle, et al.
Publicado: (2020)

Species-Specific Differences in the Expression of the HNF1A, HNF1B and HNF4A Genes
por: Harries, Lorna W., et al.
Publicado: (2009)

Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α
por: Zheng, Bai-Nan, et al.
Publicado: (2019)

Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis
por: Lee, Da-Hye, et al.
Publicado: (2020)

Improved conditional expression systems resulting in physiological level of HNF4α expression confirm HNF4α induced apoptosis in the pancreatic β-cell line INS-1
por: Senkel, Sabine, et al.
Publicado: (2009)

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells
por: Onodera, Toshiharu, et al.
Publicado: (2023)

Nuclear Receptor HNF4α Binding Sequences are Widespread in Alu Repeats
por: Bolotin, Eugene, et al.
Publicado: (2011)

Multi-Domain Integration in the Structure of the HNF4α Nuclear Receptor Complex
por: Chandra, Vikas, et al.
Publicado: (2013)

Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma
por: Fekry, Baharan, et al.
Publicado: (2018)

Hepatic Polarization Accelerated by Mechanical Compaction Involves HNF4α Activation
por: Yang, Jinlian, et al.
Publicado: (2020)

Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans
por: Florentino, Rodrigo M., et al.
Publicado: (2020)

HNF4α isoforms: the fraternal twin master regulators of liver function
por: Radi, Sarah H., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0lv25qd8hkgpiehhs1afqbue37