Cargando…

Influence of Oscillating Flow on LDL Transport and Wall Shear Stress in the Normal Aortic Arch

Lipid accumulation in the aortic wall is an important factor in the development of atherosclerosis. The Low Density Lipoprotein (LDL) at the surface of the endothelium in relation to Wall Shear Stress (WSS) in the normal human aortic arch under unsteady, normal flow and mass conditions was computati...

Descripción completa

Detalles Bibliográficos
Autores principales: Soulis, J, Giannoglou, G, Dimitrakopoulou, M, Papaioannou, V, Logothetides, S, Mikhailidis, D
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761669/
https://www.ncbi.nlm.nih.gov/pubmed/19834577
http://dx.doi.org/10.2174/1874192400903010128
_version_ 1782172844090720256
author Soulis, J
Giannoglou, G
Dimitrakopoulou, M
Papaioannou, V
Logothetides, S
Mikhailidis, D
author_facet Soulis, J
Giannoglou, G
Dimitrakopoulou, M
Papaioannou, V
Logothetides, S
Mikhailidis, D
author_sort Soulis, J
collection PubMed
description Lipid accumulation in the aortic wall is an important factor in the development of atherosclerosis. The Low Density Lipoprotein (LDL) at the surface of the endothelium in relation to Wall Shear Stress (WSS) in the normal human aortic arch under unsteady, normal flow and mass conditions was computationally analysed. Concave sides of the aortic arch exhibit, relatively to the convex ones, elevated LDL levels at the surface of the endothelium for all time steps. At the peak systolic velocity, the LDL level reaches a value 23.0% higher than that at entrance in the ascending-descending aorta region. The corresponding LDL levels at the surface of the endothelium for the near minimum entrance velocity instant reaches 26.0%. During the cardiac cycle, the highest area averaged normalized LDL taken up as compared to the lowest one is 0.69%. WSS plays an important role in the lipid accumulation. Low WSS regions are exposed to high LDL levels at the surface of the endothelium. Regions of elevated LDL levels do not necessarily co-locate to the sites of lowest WSS. The near wall paths of the velocities might be the most important factor for the elevated LDL levels at the surface of the endothelium.
format Text
id pubmed-2761669
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Bentham Open
record_format MEDLINE/PubMed
spelling pubmed-27616692009-10-15 Influence of Oscillating Flow on LDL Transport and Wall Shear Stress in the Normal Aortic Arch Soulis, J Giannoglou, G Dimitrakopoulou, M Papaioannou, V Logothetides, S Mikhailidis, D Open Cardiovasc Med J Article Lipid accumulation in the aortic wall is an important factor in the development of atherosclerosis. The Low Density Lipoprotein (LDL) at the surface of the endothelium in relation to Wall Shear Stress (WSS) in the normal human aortic arch under unsteady, normal flow and mass conditions was computationally analysed. Concave sides of the aortic arch exhibit, relatively to the convex ones, elevated LDL levels at the surface of the endothelium for all time steps. At the peak systolic velocity, the LDL level reaches a value 23.0% higher than that at entrance in the ascending-descending aorta region. The corresponding LDL levels at the surface of the endothelium for the near minimum entrance velocity instant reaches 26.0%. During the cardiac cycle, the highest area averaged normalized LDL taken up as compared to the lowest one is 0.69%. WSS plays an important role in the lipid accumulation. Low WSS regions are exposed to high LDL levels at the surface of the endothelium. Regions of elevated LDL levels do not necessarily co-locate to the sites of lowest WSS. The near wall paths of the velocities might be the most important factor for the elevated LDL levels at the surface of the endothelium. Bentham Open 2009-09-17 /pmc/articles/PMC2761669/ /pubmed/19834577 http://dx.doi.org/10.2174/1874192400903010128 Text en © Soulis et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Soulis, J
Giannoglou, G
Dimitrakopoulou, M
Papaioannou, V
Logothetides, S
Mikhailidis, D
Influence of Oscillating Flow on LDL Transport and Wall Shear Stress in the Normal Aortic Arch
title Influence of Oscillating Flow on LDL Transport and Wall Shear Stress in the Normal Aortic Arch
title_full Influence of Oscillating Flow on LDL Transport and Wall Shear Stress in the Normal Aortic Arch
title_fullStr Influence of Oscillating Flow on LDL Transport and Wall Shear Stress in the Normal Aortic Arch
title_full_unstemmed Influence of Oscillating Flow on LDL Transport and Wall Shear Stress in the Normal Aortic Arch
title_short Influence of Oscillating Flow on LDL Transport and Wall Shear Stress in the Normal Aortic Arch
title_sort influence of oscillating flow on ldl transport and wall shear stress in the normal aortic arch
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761669/
https://www.ncbi.nlm.nih.gov/pubmed/19834577
http://dx.doi.org/10.2174/1874192400903010128
work_keys_str_mv AT soulisj influenceofoscillatingflowonldltransportandwallshearstressinthenormalaorticarch
AT giannogloug influenceofoscillatingflowonldltransportandwallshearstressinthenormalaorticarch
AT dimitrakopouloum influenceofoscillatingflowonldltransportandwallshearstressinthenormalaorticarch
AT papaioannouv influenceofoscillatingflowonldltransportandwallshearstressinthenormalaorticarch
AT logothetidess influenceofoscillatingflowonldltransportandwallshearstressinthenormalaorticarch
AT mikhailidisd influenceofoscillatingflowonldltransportandwallshearstressinthenormalaorticarch