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The cis-(5R,6S)-Thymine Glycol Lesion Occupies the Wobble Position When Mismatched with Deoxyguanosine in DNA

[Image: see text] Oxidative damage to 5-methylcytosine in DNA, followed by deamination, yields thymine glycol (Tg), 5,6-dihydroxy-5,6-dihydrothymine, mispaired with deoxyguanosine. The structure of the 5R Tg·G mismatch pair has been refined using a combination of simulated annealing and isothermal m...

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Detalles Bibliográficos
Autores principales:	Brown, Kyle L., Basu, Ashis K., Stone, Michael P.
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2009
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761728/ https://www.ncbi.nlm.nih.gov/pubmed/19772348 http://dx.doi.org/10.1021/bi900695e

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