Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, ris...

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Detalles Bibliográficos
Autores principales: Benjamin, Emelia J., Rice, Kenneth M., Arking, Dan E., Pfeufer, Arne, van Noord, Charlotte, Smith, Albert V., Schnabel, Renate B., Bis, Joshua C., Boerwinkle, Eric, Sinner, Moritz F., Dehghan, Abbas, Lubitz, Steven A., D’Agostino, Ralph B., Lumley, Thomas, Ehret, Georg B., Heeringa, Jan, Aspelund, Thor, Newton-Cheh, Christopher, Larson, Martin G., Marciante, Kristin D., Soliman, Elsayed Z., Rivadeneira, Fernando, Wang, Thomas J., Eiriksdottir, Gudny, Levy, Daniel, Psaty, Bruce M., Li, Man, Chamberlain, Alanna M., Hofman, Albert, Vasan, Ramachandran S., Harris, Tamara B., Rotter, Jerome I., Kao, W.H. Linda, Agarwal, Sunil K., Ch. Stricker, Bruno H., Wang, Ke, Launer, Lenore J., Smith, Nicholas L., Chakravarti, Aravinda, Uitterlinden, Andre G., Wolf, Philip A, Sotoodehnia, Nona, Kottgen, Anna, van Duijn, Cornelia M., Lunetta, Kathryn L., Heckbert, Susan R., Gudnason, Vilmundur, Alonso, Alvaro, Kaab, Stefan, Ellinor, Patrick T., Witteman, Jacqueline C.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761746/
https://www.ncbi.nlm.nih.gov/pubmed/19597492
http://dx.doi.org/10.1038/ng.416
Descripción
Sumario:We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10(−7)), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10(−11)). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10(−15)).

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