Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, ris...

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Autores principales: Benjamin, Emelia J., Rice, Kenneth M., Arking, Dan E., Pfeufer, Arne, van Noord, Charlotte, Smith, Albert V., Schnabel, Renate B., Bis, Joshua C., Boerwinkle, Eric, Sinner, Moritz F., Dehghan, Abbas, Lubitz, Steven A., D’Agostino, Ralph B., Lumley, Thomas, Ehret, Georg B., Heeringa, Jan, Aspelund, Thor, Newton-Cheh, Christopher, Larson, Martin G., Marciante, Kristin D., Soliman, Elsayed Z., Rivadeneira, Fernando, Wang, Thomas J., Eiriksdottir, Gudny, Levy, Daniel, Psaty, Bruce M., Li, Man, Chamberlain, Alanna M., Hofman, Albert, Vasan, Ramachandran S., Harris, Tamara B., Rotter, Jerome I., Kao, W.H. Linda, Agarwal, Sunil K., Ch. Stricker, Bruno H., Wang, Ke, Launer, Lenore J., Smith, Nicholas L., Chakravarti, Aravinda, Uitterlinden, Andre G., Wolf, Philip A, Sotoodehnia, Nona, Kottgen, Anna, van Duijn, Cornelia M., Lunetta, Kathryn L., Heckbert, Susan R., Gudnason, Vilmundur, Alonso, Alvaro, Kaab, Stefan, Ellinor, Patrick T., Witteman, Jacqueline C.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761746/
https://www.ncbi.nlm.nih.gov/pubmed/19597492
http://dx.doi.org/10.1038/ng.416
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author Benjamin, Emelia J.
Rice, Kenneth M.
Arking, Dan E.
Pfeufer, Arne
van Noord, Charlotte
Smith, Albert V.
Schnabel, Renate B.
Bis, Joshua C.
Boerwinkle, Eric
Sinner, Moritz F.
Dehghan, Abbas
Lubitz, Steven A.
D’Agostino, Ralph B.
Lumley, Thomas
Ehret, Georg B.
Heeringa, Jan
Aspelund, Thor
Newton-Cheh, Christopher
Larson, Martin G.
Marciante, Kristin D.
Soliman, Elsayed Z.
Rivadeneira, Fernando
Wang, Thomas J.
Eiriksdottir, Gudny
Levy, Daniel
Psaty, Bruce M.
Li, Man
Chamberlain, Alanna M.
Hofman, Albert
Vasan, Ramachandran S.
Harris, Tamara B.
Rotter, Jerome I.
Kao, W.H. Linda
Agarwal, Sunil K.
Ch. Stricker, Bruno H.
Wang, Ke
Launer, Lenore J.
Smith, Nicholas L.
Chakravarti, Aravinda
Uitterlinden, Andre G.
Wolf, Philip A
Sotoodehnia, Nona
Kottgen, Anna
van Duijn, Cornelia M.
Lunetta, Kathryn L.
Heckbert, Susan R.
Gudnason, Vilmundur
Alonso, Alvaro
Kaab, Stefan
Ellinor, Patrick T.
Witteman, Jacqueline C.
author_facet Benjamin, Emelia J.
Rice, Kenneth M.
Arking, Dan E.
Pfeufer, Arne
van Noord, Charlotte
Smith, Albert V.
Schnabel, Renate B.
Bis, Joshua C.
Boerwinkle, Eric
Sinner, Moritz F.
Dehghan, Abbas
Lubitz, Steven A.
D’Agostino, Ralph B.
Lumley, Thomas
Ehret, Georg B.
Heeringa, Jan
Aspelund, Thor
Newton-Cheh, Christopher
Larson, Martin G.
Marciante, Kristin D.
Soliman, Elsayed Z.
Rivadeneira, Fernando
Wang, Thomas J.
Eiriksdottir, Gudny
Levy, Daniel
Psaty, Bruce M.
Li, Man
Chamberlain, Alanna M.
Hofman, Albert
Vasan, Ramachandran S.
Harris, Tamara B.
Rotter, Jerome I.
Kao, W.H. Linda
Agarwal, Sunil K.
Ch. Stricker, Bruno H.
Wang, Ke
Launer, Lenore J.
Smith, Nicholas L.
Chakravarti, Aravinda
Uitterlinden, Andre G.
Wolf, Philip A
Sotoodehnia, Nona
Kottgen, Anna
van Duijn, Cornelia M.
Lunetta, Kathryn L.
Heckbert, Susan R.
Gudnason, Vilmundur
Alonso, Alvaro
Kaab, Stefan
Ellinor, Patrick T.
Witteman, Jacqueline C.
author_sort Benjamin, Emelia J.
collection PubMed
description We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10(−7)), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10(−11)). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10(−15)).
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spelling pubmed-27617462010-02-01 Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry Benjamin, Emelia J. Rice, Kenneth M. Arking, Dan E. Pfeufer, Arne van Noord, Charlotte Smith, Albert V. Schnabel, Renate B. Bis, Joshua C. Boerwinkle, Eric Sinner, Moritz F. Dehghan, Abbas Lubitz, Steven A. D’Agostino, Ralph B. Lumley, Thomas Ehret, Georg B. Heeringa, Jan Aspelund, Thor Newton-Cheh, Christopher Larson, Martin G. Marciante, Kristin D. Soliman, Elsayed Z. Rivadeneira, Fernando Wang, Thomas J. Eiriksdottir, Gudny Levy, Daniel Psaty, Bruce M. Li, Man Chamberlain, Alanna M. Hofman, Albert Vasan, Ramachandran S. Harris, Tamara B. Rotter, Jerome I. Kao, W.H. Linda Agarwal, Sunil K. Ch. Stricker, Bruno H. Wang, Ke Launer, Lenore J. Smith, Nicholas L. Chakravarti, Aravinda Uitterlinden, Andre G. Wolf, Philip A Sotoodehnia, Nona Kottgen, Anna van Duijn, Cornelia M. Lunetta, Kathryn L. Heckbert, Susan R. Gudnason, Vilmundur Alonso, Alvaro Kaab, Stefan Ellinor, Patrick T. Witteman, Jacqueline C. Nat Genet Article We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10(−7)), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10(−11)). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10(−15)). 2009-07-13 2009-08 /pmc/articles/PMC2761746/ /pubmed/19597492 http://dx.doi.org/10.1038/ng.416 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Benjamin, Emelia J.
Rice, Kenneth M.
Arking, Dan E.
Pfeufer, Arne
van Noord, Charlotte
Smith, Albert V.
Schnabel, Renate B.
Bis, Joshua C.
Boerwinkle, Eric
Sinner, Moritz F.
Dehghan, Abbas
Lubitz, Steven A.
D’Agostino, Ralph B.
Lumley, Thomas
Ehret, Georg B.
Heeringa, Jan
Aspelund, Thor
Newton-Cheh, Christopher
Larson, Martin G.
Marciante, Kristin D.
Soliman, Elsayed Z.
Rivadeneira, Fernando
Wang, Thomas J.
Eiriksdottir, Gudny
Levy, Daniel
Psaty, Bruce M.
Li, Man
Chamberlain, Alanna M.
Hofman, Albert
Vasan, Ramachandran S.
Harris, Tamara B.
Rotter, Jerome I.
Kao, W.H. Linda
Agarwal, Sunil K.
Ch. Stricker, Bruno H.
Wang, Ke
Launer, Lenore J.
Smith, Nicholas L.
Chakravarti, Aravinda
Uitterlinden, Andre G.
Wolf, Philip A
Sotoodehnia, Nona
Kottgen, Anna
van Duijn, Cornelia M.
Lunetta, Kathryn L.
Heckbert, Susan R.
Gudnason, Vilmundur
Alonso, Alvaro
Kaab, Stefan
Ellinor, Patrick T.
Witteman, Jacqueline C.
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
title Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
title_full Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
title_fullStr Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
title_full_unstemmed Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
title_short Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
title_sort variants in zfhx3 are associated with atrial fibrillation in individuals of european ancestry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761746/
https://www.ncbi.nlm.nih.gov/pubmed/19597492
http://dx.doi.org/10.1038/ng.416
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