Ovarian cancer mouse models: a summary of current models and their limitations

Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different types of ovarian cancer are needed to understand how epithelial ovarian cancer differs from g...

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Detalles Bibliográficos
Autores principales: Fong, Miranda Y, Kakar, Sham S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762470/
https://www.ncbi.nlm.nih.gov/pubmed/19781107
http://dx.doi.org/10.1186/1757-2215-2-12
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author Fong, Miranda Y
Kakar, Sham S
author_facet Fong, Miranda Y
Kakar, Sham S
author_sort Fong, Miranda Y
collection PubMed
description Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different types of ovarian cancer are needed to understand how epithelial ovarian cancer differs from granulosa cell tumors. Many different methods have been used to generate a viable genetic model with limited success. This review focuses on the methods of various investigators and the limitations of each model in establishing a reproducible and inheritable line to study this disease.
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spelling pubmed-27624702009-10-16 Ovarian cancer mouse models: a summary of current models and their limitations Fong, Miranda Y Kakar, Sham S J Ovarian Res Review Development of mouse models representing human spontaneous ovarian cancer has been hampered by the lack of understanding of the etiology of this very complex disease. Mouse models representing the different types of ovarian cancer are needed to understand how epithelial ovarian cancer differs from granulosa cell tumors. Many different methods have been used to generate a viable genetic model with limited success. This review focuses on the methods of various investigators and the limitations of each model in establishing a reproducible and inheritable line to study this disease. BioMed Central 2009-09-28 /pmc/articles/PMC2762470/ /pubmed/19781107 http://dx.doi.org/10.1186/1757-2215-2-12 Text en Copyright © 2009 Fong and Kakar; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Fong, Miranda Y
Kakar, Sham S
Ovarian cancer mouse models: a summary of current models and their limitations
title Ovarian cancer mouse models: a summary of current models and their limitations
title_full Ovarian cancer mouse models: a summary of current models and their limitations
title_fullStr Ovarian cancer mouse models: a summary of current models and their limitations
title_full_unstemmed Ovarian cancer mouse models: a summary of current models and their limitations
title_short Ovarian cancer mouse models: a summary of current models and their limitations
title_sort ovarian cancer mouse models: a summary of current models and their limitations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762470/
https://www.ncbi.nlm.nih.gov/pubmed/19781107
http://dx.doi.org/10.1186/1757-2215-2-12
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AT kakarshams ovariancancermousemodelsasummaryofcurrentmodelsandtheirlimitations

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