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Efficient, Glucose Responsive, and Islet-Specific Transgene Expression by a Modified Rat Insulin Promoter

This study was done to improve efficiency and islet specificity of the rat insulin promoter (RIP). Various rat insulin promoter lengths were prepared and tested in vitro to drive luciferase reporter gene expression in INS1-cells, alpha-cells, acinar cells, ductal cells, and fibroblasts. The CMV prom...

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Detalles Bibliográficos
Autores principales:	Chai, Renjie, Chen, Shuyuan, Ding, Jiahuan, Grayburn, Paul A
Formato:	Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762485/ https://www.ncbi.nlm.nih.gov/pubmed/19727136 http://dx.doi.org/10.1038/gt.2009.114

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