Study of Human RIG-I Polymorphisms Identifies Two Variants with an Opposite Impact on the Antiviral Immune Response

BACKGROUND: RIG-I is a pivotal receptor that detects numerous RNA and DNA viruses. Thus, its defectiveness may strongly impair the host antiviral immunity. Remarkably, very little information is available on RIG-I single-nucleotide polymorphisms (SNPs) presenting a functional impact on the host resp...

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Detalles Bibliográficos
Autores principales: Pothlichet, Julien, Burtey, Anne, Kubarenko, Andriy V., Caignard, Gregory, Solhonne, Brigitte, Tangy, Frédéric, Ben-Ali, Meriem, Quintana-Murci, Lluis, Heinzmann, Andrea, Chiche, Jean-Daniel, Vidalain, Pierre-Olivier, Weber, Alexander N. R., Chignard, Michel, Si-Tahar, Mustapha
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762520/
https://www.ncbi.nlm.nih.gov/pubmed/19859543
http://dx.doi.org/10.1371/journal.pone.0007582

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