Cargando…

Primary effusion lymphoma involving three body cavities

Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV8)-associated large-cell non-Hodgkin lymphoma localized in body cavities and presenting as pleural, peritoneal, or pericardial lymphomatous effusions. It typically affects immunocompromised patients and usually involves only one body site...

Descripción completa

Detalles Bibliográficos
Autores principales: Brimo, Fadi, Popradi, Gizelle, Michel, René P, Auger, Manon
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762694/
https://www.ncbi.nlm.nih.gov/pubmed/19876384
http://dx.doi.org/10.4103/1742-6413.56361
_version_ 1782172949347827712
author Brimo, Fadi
Popradi, Gizelle
Michel, René P
Auger, Manon
author_facet Brimo, Fadi
Popradi, Gizelle
Michel, René P
Auger, Manon
author_sort Brimo, Fadi
collection PubMed
description Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV8)-associated large-cell non-Hodgkin lymphoma localized in body cavities and presenting as pleural, peritoneal, or pericardial lymphomatous effusions. It typically affects immunocompromised patients and usually involves only one body site. We describe herein a case of PEL affecting three body cavity sites in an immunocompetent patient. A 69-year-old HIV-negative man presented with upper gastrointestinal bleeding and ascites. An examination of the fluid by cytology showed large atypical lymphocytes with abundant basophilic cytoplasm, either central or eccentric nuclei having irregular outlines, and multiple prominent nucleoli. The neoplastic cells showed positive staining for CD45, CD3, HHV8 latent nuclear antigen (LNA), and Epstein-Barr virus-encoded RNA. A diagnosis of PEL was rendered. Despite chemotherapy and valganciclovir, the disease progressed to involve the pleural and pericardial cavities and the patient died 5 months following the initial diagnosis. Although PEL is a B-cell lymphoma, it is usually of null phenotype by immunohistochemistry, and can rarely aberrantly express T-cell markers, as seen in the current case. The key to the diagnosis of PEL rests on identifying HHV8 in the neoplastic cells. Therefore, restricting the term of PEL only to those cases that are HHV8 positive is important in order to differentiate PEL from other lymphomas that can present as serous effusions and that carry, in general, a more favorable prognosis than PEL
format Text
id pubmed-2762694
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-27626942009-10-27 Primary effusion lymphoma involving three body cavities Brimo, Fadi Popradi, Gizelle Michel, René P Auger, Manon Cytojournal Case Report Primary effusion lymphoma (PEL) is a human herpes virus-8 (HHV8)-associated large-cell non-Hodgkin lymphoma localized in body cavities and presenting as pleural, peritoneal, or pericardial lymphomatous effusions. It typically affects immunocompromised patients and usually involves only one body site. We describe herein a case of PEL affecting three body cavity sites in an immunocompetent patient. A 69-year-old HIV-negative man presented with upper gastrointestinal bleeding and ascites. An examination of the fluid by cytology showed large atypical lymphocytes with abundant basophilic cytoplasm, either central or eccentric nuclei having irregular outlines, and multiple prominent nucleoli. The neoplastic cells showed positive staining for CD45, CD3, HHV8 latent nuclear antigen (LNA), and Epstein-Barr virus-encoded RNA. A diagnosis of PEL was rendered. Despite chemotherapy and valganciclovir, the disease progressed to involve the pleural and pericardial cavities and the patient died 5 months following the initial diagnosis. Although PEL is a B-cell lymphoma, it is usually of null phenotype by immunohistochemistry, and can rarely aberrantly express T-cell markers, as seen in the current case. The key to the diagnosis of PEL rests on identifying HHV8 in the neoplastic cells. Therefore, restricting the term of PEL only to those cases that are HHV8 positive is important in order to differentiate PEL from other lymphomas that can present as serous effusions and that carry, in general, a more favorable prognosis than PEL Medknow Publications 2009-10-09 /pmc/articles/PMC2762694/ /pubmed/19876384 http://dx.doi.org/10.4103/1742-6413.56361 Text en © 2009 Brimo et al; licensee Cytopathology Foundation Inc. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Brimo, Fadi
Popradi, Gizelle
Michel, René P
Auger, Manon
Primary effusion lymphoma involving three body cavities
title Primary effusion lymphoma involving three body cavities
title_full Primary effusion lymphoma involving three body cavities
title_fullStr Primary effusion lymphoma involving three body cavities
title_full_unstemmed Primary effusion lymphoma involving three body cavities
title_short Primary effusion lymphoma involving three body cavities
title_sort primary effusion lymphoma involving three body cavities
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762694/
https://www.ncbi.nlm.nih.gov/pubmed/19876384
http://dx.doi.org/10.4103/1742-6413.56361
work_keys_str_mv AT brimofadi primaryeffusionlymphomainvolvingthreebodycavities
AT popradigizelle primaryeffusionlymphomainvolvingthreebodycavities
AT michelrenep primaryeffusionlymphomainvolvingthreebodycavities
AT augermanon primaryeffusionlymphomainvolvingthreebodycavities