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Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease

BACKGROUND: Growing evidence indicates that ambient air pollution is associated with exacerbation of chronic diseases like chronic pulmonary disease. A prospective panel study was conducted to investigate short-term changes of blood markers of inflammation and coagulation in response to daily change...

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Autores principales: Hildebrandt, Katharina, Rückerl, Regina, Koenig, Wolfgang, Schneider, Alexandra, Pitz, Mike, Heinrich, Joachim, Marder, Victor, Frampton, Mark, Oberdörster, Günter, Wichmann, H Erich, Peters, Annette
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762952/
https://www.ncbi.nlm.nih.gov/pubmed/19781092
http://dx.doi.org/10.1186/1743-8977-6-25
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author Hildebrandt, Katharina
Rückerl, Regina
Koenig, Wolfgang
Schneider, Alexandra
Pitz, Mike
Heinrich, Joachim
Marder, Victor
Frampton, Mark
Oberdörster, Günter
Wichmann, H Erich
Peters, Annette
author_facet Hildebrandt, Katharina
Rückerl, Regina
Koenig, Wolfgang
Schneider, Alexandra
Pitz, Mike
Heinrich, Joachim
Marder, Victor
Frampton, Mark
Oberdörster, Günter
Wichmann, H Erich
Peters, Annette
author_sort Hildebrandt, Katharina
collection PubMed
description BACKGROUND: Growing evidence indicates that ambient air pollution is associated with exacerbation of chronic diseases like chronic pulmonary disease. A prospective panel study was conducted to investigate short-term changes of blood markers of inflammation and coagulation in response to daily changes in air pollution in Erfurt, Germany. 12 clinical visits were scheduled and blood parameters were measured in 38 male patients with chronic pulmonary disease during winter 2001/2002. Additive mixed models with random patient intercept were applied, adjusting for trend, weekday, and meteorological parameters. Hourly data on ultrafine particles (UFP, 0.01-0.1 μm), accumulation mode particles (ACP, 0.1-1.0 μm), PM(10 )(particulate matter <10 μm in diameter), elemental (EC) and organic carbon (OC), gaseous pollutants (nitrogen monoxide [NO], nitrogen dioxide [NO(2)], carbon monoxide [CO], and sulphur dioxide [SO(2)]) were collected at a central monitoring site and meteorological data were received from an official network. For each person and visit the individual 24-hour average of pollutants immediately preceding the blood withdrawal (lag 0) up to day 5 (lag1-4) and 5-day running means were calculated. RESULTS: Increased levels of fibrinogen were observed for an increase in one interquartile range of UFP, PM(10), EC, OC, CO, and NO revealing the strongest effect for lag 3. E-selectin increased in association with ACP and PM(10 )with a delay of one day. The ACP effect was also seen with the 5-day-mean. The pattern found for D-dimer was inconsistent. Prothrombin fragment 1+2 decreased with lag 4 consistently for all particulate pollutants. Von Willebrand factor antigen (vWF) showed a consistent decrease in association with almost all air pollutants with all lags except for lag 0. No associations were found for C-reactive protein, soluble intercellular adhesion molecule 1, serum amyloid A and factor VII. CONCLUSION: These results suggest that elevated concentrations of air pollution are associated with changes in some blood markers of inflammation and coagulation in patients with chronic pulmonary disease. The clinical implications of these findings need further investigation.
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spelling pubmed-27629522009-10-17 Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease Hildebrandt, Katharina Rückerl, Regina Koenig, Wolfgang Schneider, Alexandra Pitz, Mike Heinrich, Joachim Marder, Victor Frampton, Mark Oberdörster, Günter Wichmann, H Erich Peters, Annette Part Fibre Toxicol Research BACKGROUND: Growing evidence indicates that ambient air pollution is associated with exacerbation of chronic diseases like chronic pulmonary disease. A prospective panel study was conducted to investigate short-term changes of blood markers of inflammation and coagulation in response to daily changes in air pollution in Erfurt, Germany. 12 clinical visits were scheduled and blood parameters were measured in 38 male patients with chronic pulmonary disease during winter 2001/2002. Additive mixed models with random patient intercept were applied, adjusting for trend, weekday, and meteorological parameters. Hourly data on ultrafine particles (UFP, 0.01-0.1 μm), accumulation mode particles (ACP, 0.1-1.0 μm), PM(10 )(particulate matter <10 μm in diameter), elemental (EC) and organic carbon (OC), gaseous pollutants (nitrogen monoxide [NO], nitrogen dioxide [NO(2)], carbon monoxide [CO], and sulphur dioxide [SO(2)]) were collected at a central monitoring site and meteorological data were received from an official network. For each person and visit the individual 24-hour average of pollutants immediately preceding the blood withdrawal (lag 0) up to day 5 (lag1-4) and 5-day running means were calculated. RESULTS: Increased levels of fibrinogen were observed for an increase in one interquartile range of UFP, PM(10), EC, OC, CO, and NO revealing the strongest effect for lag 3. E-selectin increased in association with ACP and PM(10 )with a delay of one day. The ACP effect was also seen with the 5-day-mean. The pattern found for D-dimer was inconsistent. Prothrombin fragment 1+2 decreased with lag 4 consistently for all particulate pollutants. Von Willebrand factor antigen (vWF) showed a consistent decrease in association with almost all air pollutants with all lags except for lag 0. No associations were found for C-reactive protein, soluble intercellular adhesion molecule 1, serum amyloid A and factor VII. CONCLUSION: These results suggest that elevated concentrations of air pollution are associated with changes in some blood markers of inflammation and coagulation in patients with chronic pulmonary disease. The clinical implications of these findings need further investigation. BioMed Central 2009-09-26 /pmc/articles/PMC2762952/ /pubmed/19781092 http://dx.doi.org/10.1186/1743-8977-6-25 Text en Copyright © 2009 Hildebrandt et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Hildebrandt, Katharina
Rückerl, Regina
Koenig, Wolfgang
Schneider, Alexandra
Pitz, Mike
Heinrich, Joachim
Marder, Victor
Frampton, Mark
Oberdörster, Günter
Wichmann, H Erich
Peters, Annette
Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
title Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
title_full Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
title_fullStr Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
title_full_unstemmed Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
title_short Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
title_sort short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762952/
https://www.ncbi.nlm.nih.gov/pubmed/19781092
http://dx.doi.org/10.1186/1743-8977-6-25
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